Molecular Mechanisms and Clinical Application of Multipotent Stem Cells for Spinal Cord Injury

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 1; p. 120
• Main Authors: Szymoniuk, Michał, Litak, Jakub, Sakwa, Leon, Dryla, Aleksandra, Zezuliński, Wojciech, Czyżewski, Wojciech, Kamieniak, Piotr, Blicharski, Tomasz
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.12.2022; MDPI
• Subjects: Analysis; Apoptosis; Care and treatment; Cell differentiation; Cell proliferation; Cell self-renewal; Cell therapy; Clinical trials; Complications; Cytotoxicity; Diagnosis; Edema; Exosomes; Hematopoietic stem cells; Humans; Literature reviews; Medical prognosis; Mesenchymal Stem Cells; Mesenchyme; Microenvironments; Molecular mechanics; Molecular modelling; multipotent stem cells; Multipotent Stem Cells - transplantation; Nanotechnology; Neural Stem Cells; Neuralgia; Pain perception; Paracrine signalling; Pathophysiology; Patients; Review; Sensation; Spasticity; Spinal cord injuries; Spinal Cord Injuries - pathology; stem cell transplantation; Stem cells; Transplantation; Tumor necrosis factor-TNF; Poland; neural stem cells; mesenchymal stem cells; regenerative medicine; stem cell transplantation; multipotent stem cells; hematopoietic stem cells; spinal cord injuries

Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and psychosocial sequelae. The majority of patients after SCI suffer from permanent disability caused by motor dysfunction, impaired sensation, neuropathic pain, spasticity as well as urinary complications, and a s...