Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells

• Published in: Biological psychiatry (1969) Vol. 83; no. 7; pp. 569 - 578
• Main Authors: Russo, Fabiele Baldino, Freitas, Beatriz Camille, Pignatari, Graciela Conceição, Fernandes, Isabella Rodrigues, Sebat, Jonathan, Muotri, Alysson Renato, Beltrão-Braga, Patricia Cristina Baleeiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018
• Subjects: ASD; Astrocytes; Autism; Co-culture model; iPSCs; Neurons; Psychiatric/Mental Health; Autism; iPSCs; ASD; Co-culture model; Astrocytes; Neurons

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with unclear etiology and imprecise genetic causes. The main goal of this work was to investigate neuronal connectivity and the interplay between neurons and astrocytes from individuals with nonsyndromic ASD using induced pluripotent st...