Circadian Regulation of the Na+/K+-Atpase Alpha Subunit in the Visual System Is Mediated by the Pacemaker and by Retina Photoreceptors in Drosophila Melanogaster

• Published in: PloS one Vol. 8; no. 9; p. e73690
• Main Authors: Damulewicz, Milena, Rosato, Ezio, Pyza, Elzbieta
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.09.2013; Public Library of Science (PLoS)
• Subjects: Abundance; Animals; Apoptosis; Brain; Catalysis; Circadian Rhythm; Circadian rhythms; Diurnal; Drosophila; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Gene expression; Immunohistochemistry; Insects; Light; Microscopy, Confocal; Mutants; Mutation; Na+/K+-exchanging ATPase; Neuronal-glial interactions; Neurons; Neurons - metabolism; Neuropeptides; Neuropil; Neuropil - metabolism; Neuroplasticity; Neurosciences; Photoreceptor Cells, Vertebrate - metabolism; Photoreceptors; Physiology; Plasticity (neural); Potassium; Proteins; Retina; Rhythm; Rhythms; RNA Interference; RNA-mediated interference; Sodium; Sodium-Potassium-Exchanging ATPase - genetics; Sodium-Potassium-Exchanging ATPase - metabolism; Visual Cortex - metabolism; Visual observation; Visual plasticity; Visual system; Zoology; Poland

We investigated the diurnal oscillation in abundance of the catalytic α subunit of the sodium/potassium pump (ATPα) in the brain of Drosophila melanogaster. This rhythm is bimodal and is particularly robust in the glia cells of the lamina, the first optic neuropil. We observed loss of ATPα cycling i...