Short- and medium-chain fatty acids in energy metabolism: the cellular perspective

• Published in: Journal of lipid research Vol. 57; no. 6; pp. 943 - 954
• Main Authors: Schönfeld, Peter, Wojtczak, Lech
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Acyl Coenzyme A - metabolism; Adenosine Triphosphate - biosynthesis; Adenosine Triphosphate - metabolism; Carnitine - metabolism; Energy Metabolism; Fatty Acids - biosynthesis; Fatty Acids - metabolism; Humans; long-chain fatty acids; mitochondria; Mitochondria - metabolism; Oxidation-Reduction; Reviews; short-chain fatty acids; Triglycerides - metabolism; short-chain fatty acids; long-chain fatty acids; mitochondria

Short- and medium-chain fatty acids (SCFAs and MCFAs), independently of their cellular signaling functions, are important substrates of the energy metabolism and anabolic processes in mammals. SCFAs are mostly generated by colonic bacteria and are predominantly metabolized by enterocytes and liver,...