Time-Varying Pattern of Postoperative Recurrence Risk of Early-Stage (T1a-T2bN0M0) Non-Small Cell Lung Cancer (NSCLC): Results of a Single-Center Study of 994 Chinese Patients

• Published in: PloS one Vol. 9; no. 9; p. e106668
• Main Authors: Zhu, Jian-fei, Feng, Xing-yu, Zhang, Xue-wen, Wen, Ying-sheng, Lin, Peng, Rong, Tie-hua, Cai, Ling, Zhang, Lan-jun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.09.2014; Public Library of Science (PLoS)
• Subjects: Aged; Cancer; Cancer therapies; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - surgery; Chemotherapy; Chemotherapy, Adjuvant; China; DNA methylation; Female; Health hazards; Health risks; Humans; Identification methods; Lung cancer; Lung diseases; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Medical prognosis; Medicine and Health Sciences; Middle Aged; Neoplasm Staging; Non-small cell lung carcinoma; Patients; Postoperative Period; Recurrence; Retrospective Studies; Review boards; Risk; Subgroups; Surgery; Survival; Survival Analysis; Temporal distribution; Thoracic surgery; Time Factors; China

The aim of this study was to analyze the time-varying pattern of recurrence risk of early-stage (T1a-T2bN0M0) non-small cell lung cancer (NSCLC) after surgery using the hazard function and identify patients who might benefit from adjuvant chemotherapy. This retrospective study enrolled 994 patients...