Switching of Pyruvate Kinase Isoform L to M2 Promotes Metabolic Reprogramming in Hepatocarcinogenesis

• Published in: PloS one Vol. 9; no. 12; p. e115036
• Main Authors: Wong, Carmen Chak-Lui, Au, Sandy Leung-Kuen, Tse, Aki Pui-Wah, Xu, Iris Ming-Jing, Lai, Robin Kit-Ho, Chiu, David Kung-Chun, Wei, Larry Lai, Fan, Dorothy Ngo-Yin, Tsang, Felice Ho-Ching, Lo, Regina Cheuk-Lam, Wong, Chun-Ming, Ng, Irene Oi-Lin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.12.2014; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Biotechnology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Line, Tumor; Cell Proliferation; Female; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Glucose; Glycolysis; Hep G2 Cells; Hepatocellular carcinoma; Homeostasis; Humans; Implantation; In vivo methods and tests; Kinases; Laboratories; Liver; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Neoplasms, Experimental; Lung Neoplasms - pathology; Lung Neoplasms - secondary; Lungs; Male; Medicine and Health Sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Metabolism; Metastases; Metastasis; Mice; Mice, Nude; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular modelling; Overexpression; Pathology; Phosphorylation; Prognosis; Pyruvate kinase; Pyruvic acid; Ribonucleic acid; RNA; Stem cells; Stomach cancer; Surgical implants; Thyroid Hormone-Binding Proteins; Thyroid Hormones - genetics; Thyroid Hormones - metabolism; Tumors; Hong Kong China; China

Hepatocellular carcinoma (HCC) is an aggressive tumor, with a high mortality rate due to late symptom presentation and frequent tumor recurrences and metastasis. It is also a rapidly growing tumor supported by different metabolic mechanisms; nevertheless, the biological and molecular mechanisms invo...