Binding of the Heterogeneous Ribonucleoprotein K (hnRNP K) to the Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Enhances Viral LMP2A Expression

• Published in: PloS one Vol. 7; no. 8; p. e42106
• Main Authors: Gross, Henrik, Hennard, Christine, Masouris, Ilias, Cassel, Christian, Barth, Stephanie, Stober-Grässer, Ute, Mamiani, Alfredo, Moritz, Bodo, Ostareck, Dirk, Ostareck-Lederer, Antje, Neuenkirchen, Nils, Fischer, Utz, Deng, Wen, Leonhardt, Heinrich, Noessner, Elfriede, Kremmer, Elisabeth, Grässer, Friedrich A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.08.2012; Public Library of Science (PLoS)
• Subjects: Antibodies, Monoclonal - immunology; Antibody Specificity - immunology; Antigens; Arginine; Arginine - analogs & derivatives; Arginine - metabolism; Binding; Biochemistry; Biology; Cell Line; Cell survival; Cellular structure; Coding; Conserved sequence; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA methylation; E coli; Environmental health; Enzymes; Epitopes; Epstein-Barr virus; Epstein-Barr Virus Infections - metabolism; Epstein-Barr Virus Nuclear Antigens - chemistry; Epstein-Barr Virus Nuclear Antigens - immunology; Epstein-Barr Virus Nuclear Antigens - metabolism; Gene expression; Gene Expression Regulation, Viral; Glycine; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - physiology; Heterogeneous-Nuclear Ribonucleoprotein K - metabolism; Homology; Humans; Immunoglobulins; Immunology; Immunoprecipitation; Intensive care; LMP2A protein; Lymphocytes; Lymphocytes B; Medical schools; Medicine; Membrane proteins; Methylation; Molecular Sequence Data; Monoclonal antibodies; Motor neurons; Multiprotein Complexes - metabolism; Mutant Proteins - metabolism; Promoter Regions, Genetic - genetics; Protein Binding; Protein Transport; Proteins; Repetitive Sequences, Amino Acid; Ribonucleoprotein K; snRNP Core Proteins - metabolism; Surface structure; Transcription factors; Transfection; Transformation; Viral Matrix Proteins - genetics; Viral Matrix Proteins - metabolism; Viral Proteins - chemistry; Viral Proteins - immunology; Viral Proteins - metabolism; Virology; Viruses; Aachen Germany; Germany

The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs. Its Arginine-Glycine (RG) repeat element contains either symmetrically or asymmetrically...