Imaging Linear Birefringence and Dichroism in Cerebral Amyloid Pathologies

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 100; no. 26; pp. 15294 - 15298
• Main Authors: Jin, Lee-Way, Claborn, Kacey A., Kurimoto, Miki, Geday, Morten A., Maezawa, Izumi, Sohraby, Faranak, Estrada, Marcus, Kaminksy, Werner, Kahr, Bart
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.12.2003; National Acad Sciences
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - pathology; Alzheimer's disease; Alzheimers disease; Amyloid Neuropathies - pathology; Amyloids; Anisotropy; Birefringence; Blood vessels; Brain - pathology; Circular Dichroism; Coloring Agents; Crystallization; Dichroism; Downs syndrome; Gerstmann-Straussler-Scheinker Disease - pathology; Humans; Imaging; Light microscopy; Medical imaging; Molecules; Optical analysis; Physical Sciences; Plaque, Amyloid - pathology; Postmortem Changes; Prion diseases; Proteins; Solar fibrils; Telencephalon - pathology

New advances in polarized light microscopy were used to image Congo red-stained cerebral amyloidosis in sharp relief. The rotating-polarizer method was used to separate the optical effects of transmission, linear birefringence, extinction, linear dichroism, and orientation of the electric dipole tra...