Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents

• Published in: PloS one Vol. 13; no. 10; p. e0205061
• Main Authors: Takeda, Shogo, Shimoda, Hiroshi, Takarada, Toru, Imokawa, Genji
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.10.2018; Public Library of Science (PLoS)
• Subjects: Atopic dermatitis; Berries; Biology and Life Sciences; Ceramide; Ceramide glucosyltransferase; Cytokines; Dermatitis; Enzymes; Equivalence; Fatty acids; Fruits; Gene expression; Glucosylceramidase; Homeostasis; Inflammation; Lipids; Metabolism; mRNA; Palmitoyltransferase; Peroxisome proliferator-activated receptors; Physical Sciences; Proteins; R&D; Research & development; Research and Analysis Methods; Ribonucleic acid; RNA; Seeds; Serine; Serine palmitoyltransferase; Skin; Skin diseases; Sphingomyelin; Sphingomyelin phosphodiesterase; Stratum corneum; Synthesis; Western blotting; Japan

The activation of peroxisomeproliferator-activated receptor (PPAR) α can stimulate the expression of ceramide-related enzymes, and a major component of strawberry seed extract (SSE) tiliroside enhances the expression of PPARα. We determined whether SSE and tiliroside may stimulate ceramide synthesis...