Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease

• Published in: Neurobiology of aging Vol. 51; pp. 132 - 140
• Main Authors: Kreisl, William C., Lyoo, Chul Hyoung, Liow, Jeih-San, Snow, Joseph, Page, Emily, Jenko, Kimberly J., Morse, Cheryl L., Zoghbi, Sami S., Pike, Victor W., Turner, R. Scott, Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2017
• Subjects: Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid - metabolism; Atrophy; Female; Glucose - metabolism; Humans; Internal Medicine; Male; Microglia - pathology; Middle Aged; Nerve Degeneration; Neuroinflammation; Neurology; Occipital Lobe - diagnostic imaging; Occipital Lobe - metabolism; Occipital Lobe - pathology; PET imaging; Positron-Emission Tomography; Protein Binding; Receptors, GABA - metabolism; PET imaging; Neuroinflammation; Alzheimer's disease

We sought to determine whether patients with posterior cortical atrophy (PCA) demonstrate a pattern of binding to translocator protein 18 kDa, a marker of microglial activation, that is distinct from that in patients with amnestic presentation of Alzheimer's disease (AD). Eleven PCA patients, 1...