Aromatase Knockout Mice Show Normal Steroid-Induced Activation of Gonadotrophin-Releasing Hormone Neurones and Luteinising Hormone Surges With a Reduced Population of Kisspeptin Neurones in the Rostral Hypothalamus

• Published in: Journal of neuroendocrinology Vol. 24; no. 9; pp. 1222 - 1233
• Main Authors: Szymanski, L., Bakker, J.
• Format: Journal Article Web Resource
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2012; Blackwell; Wiley Subscription Services, Inc; Wiley
• Subjects: Animals; Aromatase; Aromatase - genetics; Aromatase - physiology; Aromatase/genetics/physiology; Benzoic acid; Biological and medical sciences; Cell Count - methods; Cell Count - statistics & numerical data; Cell Count/methods/statistics & numerical data; Estradiol - analogs & derivatives; Estradiol - pharmacology; Estradiol - physiology; Estradiol/analogs & derivatives/pharmacology/physiology; Female; Fos protein; Fundamental and applied biological sciences. Psychology; Gonadotropin-releasing hormone; Gonadotropin-Releasing Hormone - physiology; Hormones; hypothalamus; Hypothalamus - metabolism; Hypothalamus - physiology; Hypothalamus/metabolism/physiology; Kiss1 protein; kisspeptin; Kisspeptins - metabolism; Luteinizing hormone; Luteinizing Hormone - blood; Luteinizing Hormone - secretion; Luteinizing Hormone/blood/secretion; Male; Mice; Mice, Inbred ICR; Mice, Knockout; mRNA; Neurons - cytology; Neurons - drug effects; Neurons - physiology; Neurons/cytology/drug effects/physiology; Neurosciences & behavior; Neurosciences & comportement; oestradiol; Pituitary (anterior); Progesterone; Progesterone - pharmacology; Sciences sociales & comportementales, psychologie; Sex; Sex Characteristics; Sex differentiation; Sex Differentiation - physiology; Sex hormones; Sexual behavior; sexual differentiation; Social & behavioral sciences, psychology; Ventricles (cerebral); Vertebrates: endocrinology; Steroid; aromatase; Enzyme; Estrogen; Rodentia; Central nervous system; Gonadotropin RH; oestradiol; Activation; Estrogen synthase; Hypothalamus; Estradiol; Ovarian hormone; Encephalon; Hypothalamic hormone; Kisspeptin; Vertebrata; Mammalia; Mouse; Animal; Mutation; Hormone releasing factor; Sex steroid hormone; Sexual differentiation

We recently reported that female aromatase knockout (ArKO) mice show deficits in sexual behaviour and a decreased population of kisspeptin‐immunoreactive neurones in the rostral periventricular area of the third ventricle (RP3V), resurrecting the question of whether oestradiol actively contributes t...