Strongyloidiasis and Infective Dermatitis Alter Human T Lymphotropic Virus-1 Clonality in vivo

• Published in: PLoS pathogens Vol. 9; no. 4; p. e1003263
• Main Authors: Gillet, Nicolas A., Cook, Lucy, Laydon, Daniel J., Hlela, Carol, Verdonck, Kristien, Alvarez, Carolina, Gotuzzo, Eduardo, Clark, Daniel, Farré, Lourdes, Bittencourt, Achiléa, Asquith, Becca, Taylor, Graham P., Bangham, Charles R. M.
• Format: Journal Article Web Resource
• Language: English
• Published: United States Public Library of Science 01.04.2013; Public Library of Science (PLoS)
• Subjects: Adult; Animals; Bacterial infections; Biology; Chromosome mapping; Cloning; Coinfection; Colleges & universities; Dermatitis; Dermatitis - complications; Disease; Genetic aspects; Hematology; HTLV-I (Virus); HTLV-I Infections - complications; HTLV-I Infections - virology; Human health sciences; Human T-lymphotropic virus 1 - genetics; Human T-lymphotropic virus 1 - physiology; Humans; Hématologie; Immune response; Infections; Leukemia; Leukemia-Lymphoma, Adult T-Cell - virology; Lymphoma; Medicine; Middle Aged; Properties; Proviruses - physiology; Risk Factors; Sciences de la santé humaine; Strongyloides stercoralis; Strongyloidiasis - complications; Strongyloidiasis - parasitology; T cells; T-Lymphocytes - virology; Viral Load; Brazil; United Kingdom; Peru

Human T-lymphotropic Virus-1 (HTLV-1) is a retrovirus that persists lifelong by driving clonal proliferation of infected T-cells. HTLV-1 causes a neuroinflammatory disease and adult T-cell leukemia/lymphoma. Strongyloidiasis, a gastrointestinal infection by the helminth Strongyloides stercoralis, an...