Pedigree-Based Gene Mapping Supports Previous Loci and Reveals Novel Suggestive Loci in Specific Language Impairment

• Published in: Journal of speech, language, and hearing research Vol. 63; no. 12; pp. 4046 - 4061
• Main Authors: Andres, Erin M, Earnest, Kathleen Kelsey, Smith, Shelley D, Rice, Mabel L, Raza, Muhammad Hashim
• Format: Journal Article
• Language: English
• Published: United States American Speech-Language-Hearing Association 01.12.2020
• Subjects: Articulation (Speech); Biochemistry; Children; Chromosome Mapping; Chromosomes; Cognitive Development; Communication Disorders; Delayed language acquisition; Delayed Speech; Developmental Delays; Environmental Influences; Expressive Language; Families & family life; Family (Sociological Unit); Gene loci; Genetic aspects; Genetic Disorders; Genetic Predisposition to Disease - genetics; Genetics; Genomics; Genotype & phenotype; Hearing disorders; Hearing Impairments; Hearing loss; Humans; Identification; Identification and classification; Intellectual disabilities; Intelligence Quotient; Intelligence Tests; Language; Language acquisition; Language Aptitude; Language disorders; Language Impairments; Language Skills; Language Tests; Lod Score; Longitudinal Studies; Maturity (Individuals); Methods; Mutation; Nonparametric Statistics; Numbers; Pedigree; Quantitative trait loci; Scientific Research; Short Term Memory; Specific Language Disorder; Specific language impairment; Speech Tests; Standard scores; Teaching Methods; Tests; Twins; Kansas; United States

Purpose: Specific language impairment (SLI) is characterized by a delay in language acquisition despite a lack of other developmental delays or hearing loss. Genetics of SLI is poorly understood. The purpose of this study is to identify SLI genetic loci through family-based linkage mapping. Method:...