Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization

Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pat...

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Published inEvidence-based complementary and alternative medicine Vol. 2019; no. 2019; pp. 1 - 13
Main Authors Lai, Hsiang-Chun, Hsieh, Ching-Liang, Lin, Yi-Wen
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2019
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Acupuncture
Analgesia
Analgesics
Arthritis
Aspartate
Aspartic acid
Backache
Brain research
Care and treatment
Cytokines
Gastroenterology
Glutamic acid receptors
Headache
Hyperalgesia
Inflammation
Integrative medicine
Intestine
Irritable bowel syndrome
Low back pain
Medicine
Methyl aspartate
N-Methyl-D-aspartic acid
Neuralgia
Opioids
Osteoarthritis
Pain
Pain perception
Review
Rodents
Serotonin
Spinal cord
Taiwan
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Abstract Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. We summarized that acupuncture enhances the descending inhibitory effect and modulates the feeling of pain, thus modifying central sensitization. The possible mechanisms underlying the analgesic effects of acupuncture include segmental inhibition and the activation of the endogenous opioid, adrenergic, 5-hydroxytryptamine, and N-methyl-D-aspartic acid, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate pathways. Moreover, acupuncture can locally reduce the levels of inflammatory mediators. In clinical settings, acupuncture can be used to treat headache, neuropathic pain, low back pain, osteoarthritis, and irritable bowel syndrome. These mechanisms of acupuncture analgesia may be involved in the alleviation of central sensitization.
AbstractList Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. We summarized that acupuncture enhances the descending inhibitory effect and modulates the feeling of pain, thus modifying central sensitization. The possible mechanisms underlying the analgesic effects of acupuncture include segmental inhibition and the activation of the endogenous opioid, adrenergic, 5-hydroxytryptamine, and N-methyl-D-aspartic acid, α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate pathways. Moreover, acupuncture can locally reduce the levels of inflammatory mediators. In clinical settings, acupuncture can be used to treat headache, neuropathic pain, low back pain, osteoarthritis, and irritable bowel syndrome. These mechanisms of acupuncture analgesia may be involved in the alleviation of central sensitization.
Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. We summarized that acupuncture enhances the descending inhibitory effect and modulates the feeling of pain, thus modifying central sensitization. The possible mechanisms underlying the analgesic effects of acupuncture include segmental inhibition and the activation of the endogenous opioid, adrenergic, 5-hydroxytryptamine, and N-methyl-D-aspartic acid, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate pathways. Moreover, acupuncture can locally reduce the levels of inflammatory mediators. In clinical settings, acupuncture can be used to treat headache, neuropathic pain, low back pain, osteoarthritis, and irritable bowel syndrome. These mechanisms of acupuncture analgesia may be involved in the alleviation of central sensitization.
Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. We summarized that acupuncture enhances the descending inhibitory effect and modulates the feeling of pain, thus modifying central sensitization. The possible mechanisms underlying the analgesic effects of acupuncture include segmental inhibition and the activation of the endogenous opioid, adrenergic, 5-hydroxytryptamine, and N-methyl-D-aspartic acid, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate pathways. Moreover, acupuncture can locally reduce the levels of inflammatory mediators. In clinical settings, acupuncture can be used to treat headache, neuropathic pain, low back pain, osteoarthritis, and irritable bowel syndrome. These mechanisms of acupuncture analgesia may be involved in the alleviation of central sensitization.
Audience Academic
Author Lin, Yi-Wen
Lai, Hsiang-Chun
Hsieh, Ching-Liang
AuthorAffiliation 1 Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan
5 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
2 Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
4 Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 40402, Taiwan
3 Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan
AuthorAffiliation_xml – name: 4 Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 40402, Taiwan
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– name: 3 Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30984277$$D View this record in MEDLINE/PubMed
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Copyright © 2019 Hsiang-Chun Lai et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
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PublicationTitle Evidence-based complementary and alternative medicine
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PublicationYear 2019
Publisher Hindawi Publishing Corporation
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
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Snippet Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed...
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SubjectTerms Acupuncture
Analgesia
Analgesics
Arthritis
Aspartate
Aspartic acid
Backache
Brain research
Care and treatment
Cytokines
Gastroenterology
Glutamic acid receptors
Headache
Hyperalgesia
Inflammation
Integrative medicine
Intestine
Irritable bowel syndrome
Low back pain
Medicine
Methyl aspartate
N-Methyl-D-aspartic acid
Neuralgia
Opioids
Osteoarthritis
Pain
Pain perception
Review
Rodents
Serotonin
Spinal cord
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Title Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization
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Volume 2019
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