HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma

• Published in: Redox biology Vol. 58; p. 102546
• Main Authors: Yuan, Jingsheng, Lv, Tao, Yang, Jian, Wu, Zhenru, Yan, Lvnan, Yang, Jiayin, Shi, Yujun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2022; Elsevier
• Subjects: Carcinoma, Hepatocellular - metabolism; Ferroptosis; Ferroptosis - genetics; FSP1; HDLBP; Hepatocellular carcinoma; Humans; Liver Neoplasms - metabolism; lncRNA; Research Paper; RNA, Long Noncoding; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Tripartite Motif Proteins - metabolism; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; HDLBP; Hepatocellular carcinoma; Ferroptosis; Ubiquitination; lncRNA; FSP1

Recent studies have suggested that exploring the potential mechanisms regulating ferroptosis vulnerability may contribute to improving the systemic therapeutic efficacy in HCC. High-density lipoprotein-binding protein (HDLBP), the largest RNA-binding protein, is an important transporter that protect...