miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop

• Published in: Journal of experimental & clinical cancer research Vol. 37; no. 1; pp. 152 - 11
• Main Authors: Zhang, Feifei, Li, Kaitao, Pan, Mingxin, Li, Weidong, Wu, Juan, Li, Mingyi, Zhao, Liang, Wang, Hui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.07.2018; BioMed Central; BMC
• Subjects: Analysis; Animals; Breast cancer; Cell growth; Cell Line, Tumor; Cytokines; Development and progression; DNA methylation; Experiments; Feedback; Feedback loop; Female; Gastric cancer; Gene expression; Genetic aspects; Health aspects; Humans; Kinases; Laboratories; Leukemia; LIFR; Liver cancer; Male; Medical prognosis; Metastasis; Mice; Mice, Nude; MicroRNA; MicroRNAs; MicroRNAs - metabolism; miR-589; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases - metabolism; Physiological aspects; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Tumorigenesis; China; United States > US; Feedback loop; LIFR; miR-589; Metastasis; Gastric cancer

As novel biomarkers for various cancers, microRNAs negatively regulate genes expression via promoting mRNA degradation and suppressing mRNA translation. miR-589 has been reported to be deregulated in several human cancer types. However, its biological role has not been functionally characterized in...