Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 47; pp. 19403 - 19407
• Main Authors: Baum, Bruce J, Alevizos, Ilias, Zheng, Changyu, Cotrim, Ana P, Liu, Shuying, McCullagh, Linda, Goldsmith, Corinne M, Burbelo, Peter D, Citrin, Deborah E, Mitchell, James B, Nottingham, Liesl K, Rudy, Susan F, Van Waes, Carter, Whatley, Millie A, Brahim, Jaime S, Chiorini, John A, Danielides, Stamatina, Turner, R. James, Patronas, Nicholas J, Chen, Clara C, Nikolov, Nikolay P, Illei, Gabor G
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 20.11.2012; National Acad Sciences
• Subjects: Adenoviridae - genetics; Adenoviruses; Aged; Aquaporin 1 - genetics; Aquaporin 1 - therapeutic use; Biological Sciences; chemistry; Citrates; Clinical trials; Complementary DNA; Cytotoxicity; DNA, Complementary - genetics; Dosage; Exocrine glands; Flow velocity; Gallium; Genetic Therapy - adverse effects; Genetic vectors; Head & neck cancer; head and neck neoplasms; hematology; Humans; Male; Middle Aged; Oncology; Parotid gland; particles; patients; Proteins; Radiation Injuries - diagnostic imaging; Radiation Injuries - genetics; Radiation Injuries - therapy; Radiation therapy; Radionuclide Imaging; radiotherapy; Saliva; Salivary Gland Diseases - diagnostic imaging; Salivary Gland Diseases - etiology; Salivary Gland Diseases - physiopathology; Salivary Gland Diseases - therapy; Salivary gland neoplasms; Salivary glands; serotypes; toxicity; Transponders

No conventional therapy exists for salivary hypofunction in surviving head and neck cancer patients with Radiation Therapy Oncology Group late grade 2–3 toxicity. We conducted a phase I clinical trial to test the safety and biologic efficacy of serotype 5, adenoviral-mediated aquaporin-1 cDNA transf...