Antibiotic-manufacturing sites are hot-spots for the release and spread of antibiotic resistance genes and mobile genetic elements in receiving aquatic environments

• Published in: Environment international Vol. 130; p. 104735
• Main Authors: González-Plaza, Juan José, Blau, Khald, Milaković, Milena, Jurina, Tamara, Smalla, Kornelia, Udiković-Kolić, Nikolina
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2019; Elsevier
• Subjects: Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacology; Antibiotic pollution; Antibiotic resistance; Bacteria - drug effects; Bacteria - genetics; Drug Industry; Drug Resistance, Microbial - drug effects; Drug Resistance, Microbial - genetics; Genes, Bacterial - genetics; IncP-1; Industrial Waste - adverse effects; Industrial Waste - analysis; Interspersed Repetitive Sequences - genetics; intI1; Manufacturing; Plasmid capture; Rivers - chemistry; IncP-1; Manufacturing; intI1; Plasmid capture; Antibiotic pollution; Antibiotic resistance

High antibiotic releases from manufacturing facilities have been identified as a risk factor for antibiotic resistance development in bacterial pathogens. However, the role of antibiotic pollution in selection and transferability of antibiotic resistance genes (ARGs) is still limited. In this study,...