Critical role of AMPK in redox regulation under glucose starvation

• Published in: Redox biology Vol. 25; p. 101154
• Main Authors: Ren, Yi, Shen, Han-Ming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2019; Elsevier
• Subjects: AMP-Activated Protein Kinases - metabolism; AMPK; Animals; Cancer; Fatty acid metabolism; Glucose - deficiency; Glucose metabolism; Humans; Neoplasms - enzymology; Neoplasms - pathology; Oxidation-Reduction; Oxidative Stress; Reactive oxygen species; Reactive Oxygen Species - metabolism; G-6P; HK; MTP; PTEN; KEAP1; OXPHOS; HIF-1α; IDH; 6P-G; ERK2; PI3K; PPAR; TRIM28; CPT1; ME; mTOR; SCD1; Trx; G6PD; SREBP; Fatty acid metabolism; TSC2; CaMKKβ; MAPK; 6PGD; GPx; MEF; RAPTOR; MEK; PDAC; R-5P; TCA; ARE; 2DG; CRC; NOX; CAT; ROS; AMPK; AICAR; ULK1; DHA; GAPDH; mTORC1; CRM; NADPH; Reactive oxygen species; 2DG-6P; COX-2; HO-1; LKB1; Glucose metabolism; PPP; NADH; NRF2; α-KG; UCP2; NADP; MAGE A3/6; GSH; 6P-2DG; ACC; GLUT1; GSSG; NQO1; KO; NSCLC; SGLT2; 5TG; SOD; 3PG; BRAF; FADH2; PGC-1α; GR; ECM; NAC; ETC; FAO; FASN; FAS; UBE2O; KRAS; TP; HNE; Cancer; Glc

Glucose starvation is one of the major forms of metabolic stress in cancer cells. Deprivation of glucose impairs glycolysis and the pentose phosphate pathway, which elicits oxidative stress due to enhanced production of reactive oxygen species (ROS) and impaired antioxidant system, leading to redox...