Claudin-5: gatekeeper of neurological function

• Published in: Fluids and barriers of the CNS Vol. 16; no. 1; pp. 3 - 15
• Main Authors: Greene, Chris, Hanley, Nicole, Campbell, Matthew
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.01.2019; BioMed Central; BMC
• Subjects: Angiogenesis; Animals; Blood vessels; Blood-Brain Barrier - metabolism; Blood–brain barrier; Cell adhesion & migration; Central nervous system; Claudin-5; Claudin-5 - metabolism; Endothelial cell; Endothelial cells; Endothelium; Epilepsy; Health aspects; Homeostasis; Humans; Inflammation; Mental disorders; Mental illness; Metabolism; Multiple sclerosis; Nervous system; Nervous system diseases; Neurodegenerative diseases; Neurophysiology; Pain; Permeability; Proteins; Review; Rodents; Schizophrenia; Tight junction; United States > US; Claudin-5; Tight junction; Endothelial cell; Blood–brain barrier

Tight junction proteins of the blood-brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial cells creates a dynamic, highly regulated and restrictive microenvironment that is vital fo...