Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy

• Published in: Journal of experimental & clinical cancer research Vol. 38; no. 1; p. 403
• Main Authors: Yin, Zhongping, Bai, Ling, Li, Wei, Zeng, Tanlun, Tian, Huimin, Cui, Jiuwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.09.2019; BioMed Central; BMC
• Subjects: Amino acids; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Cancer; Cancer research; Cancer treatment; Cell differentiation; Drug development; Energy Metabolism - drug effects; Health aspects; Humans; Immune response; Immunotherapy; Lymphocytes; Metabolic reprogramming; Metabolism; Molecular Targeted Therapy; Neoplasms - drug therapy; Neoplasms - etiology; Neoplasms - metabolism; Neoplasms - pathology; Review; T cell; T cells; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumor Microenvironment - drug effects; Tumor Microenvironment - immunology; Tumors; Metabolic reprogramming; Immunotherapy; T cell; Cancer

T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulating cellular metabolic pathways and the identification of new targets may provide new optio...