β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D - Trian, Thomas; Burgess, Janette K.; Niimi, Kyoko; Moir, Lyn M.; Ge, Qi; Berger, Patrick; Liggett, Stephen B.; Black, Judith L.; Oliver, Brian G. (PloS one, 2011)
Keywords: Adrenergic beta-2 Receptor Agonists - pharmacology; Allergies; Asthma; Asthma - enzymology; Asthma - pathology; Biodegradation; Biology; Bronchodilation; Bronchodilators; Cell culture; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Chronic obstructive pulmonary disease; Cyclic AMP; Cyclic AMP - metabolism; Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Discipline; Ethics; Formoterol; Forskolin; Growth factors; Humans; Inflammation; Inhibition; Inhibitors; Isoproterenol; Isoproterenol - pharmacology; Lung - pathology; Medical research; Medicine; Muscle, Smooth - drug effects; Muscle, Smooth - enzymology; Muscle, Smooth - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - enzymology; Myocytes, Smooth Muscle - pathology; Pharmacology; Phenotype; Phosphodiesterase; Phosphodiesterase Inhibitors - pharmacology; Respiratory tract; Smooth muscle; Studies; Australia; New South Wales Australia