Molecular pattern of lncRNAs in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. Over the past decade, many studies have demonstrated the important regulatory roles of long...

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Published inJournal of experimental & clinical cancer research Vol. 38; no. 1; pp. 198 - 15
Main Authors Mai, Haoming, Zhou, Bin, Liu, Li, Yang, Fu, Conran, Carly, Ji, Yuan, Hou, Jinlin, Jiang, Deke
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 16.05.2019
BioMed Central
BMC
Subjects
Binding sites
Classification
Deoxyribonucleic acid
DNA
Gene expression
Genomes
Hepatocellular carcinoma
Hepatology
Liver cancer
lncRNA
Medical prognosis
Molecular pattern
Physiology
Polymorphism
Prostate cancer
Proteins
Regulation of biological processes
Review
RNA polymerase
Well-characterized mechanism
Hepatocellular carcinoma
lncRNA
Molecular pattern
Well-characterized mechanism
Regulation of biological processes
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Summary:Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. Over the past decade, many studies have demonstrated the important regulatory roles of long non-coding RNAs (lncRNAs) in HCC. Here, we comprehensively review recent discoveries regarding HCC-associated lncRNA functions, which we have classified and described according to their mechanism models.
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ISSN:1756-9966
0392-9078
1756-9966
DOI:10.1186/s13046-019-1213-0