Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence - Mao, Zhiyong; Tian, Xiao; Van Meter, Michael; Ke, Zhonghe; Gorbunova, Vera; Seluanov, Andrei (Proceedings of the National Academy of Sciences - PNAS, 2012)
Keywords: Adenosine diphosphate; Age; Age Factors; Aging; Biological Sciences; Cell cycle; Cell Line; Cell lines; cell senescence; Cells; Cellular senescence; Cellular Senescence - physiology; Chromosomes; Delta cells; Deoxyribonucleic acid; DNA; DNA Breaks, Double-Stranded; DNA repair; Fibroblasts; Flow Cytometry; Fluorescent Antibody Technique; Gene conversion; genome; Genomic Instability; Genomics; homologous recombination; Homologous Recombination - genetics; Homologous Recombination - physiology; Humans; Lymphocytes; middle-aged adults; NAD ADP-ribosyltransferase; neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases - metabolism; Polymerase Chain Reaction; Proteins; Sirtuins - metabolism; Tissues; Transfection