Skeletal Muscle AMP-activated Protein Kinase Is Essential for the Metabolic Response to Exercise in Vivo

• Published in: The Journal of biological chemistry Vol. 284; no. 36; pp. 23925 - 23934
• Main Authors: Lee-Young, Robert S., Griffee, Susan R., Lynes, Sara E., Bracy, Deanna P., Ayala, Julio E., McGuinness, Owen P., Wasserman, David H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.09.2009; American Society for Biochemistry and Molecular Biology
• Subjects: AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; Animals; Enzyme Activation - physiology; Female; Glucose - physiology; Male; Metabolism and Bioenergetics; Mice; Mice, Transgenic; Muscle, Skeletal - enzymology; Nitric Oxide Synthase Type I - genetics; Nitric Oxide Synthase Type I - metabolism; Physical Conditioning, Animal - physiology; Physical Endurance - physiology

AMP-activated protein kinase (AMPK) has been postulated as a super-metabolic regulator, thought to exert numerous effects on skeletal muscle function, metabolism, and enzymatic signaling. Despite these assertions, little is known regarding the direct role(s) of AMPK in vivo, and results obtained in...