Hepatitis B e antigen induces the expansion of monocytic myeloid-derived suppressor cells to dampen T-cell function in chronic hepatitis B virus infection

• Published in: PLoS pathogens Vol. 15; no. 4; p. e1007690
• Main Authors: Yang, Feifei, Yu, Xueping, Zhou, Chenliang, Mao, Richeng, Zhu, Mengqi, Zhu, Haoxiang, Ma, Zhenxuan, Mitra, Bidisha, Zhao, Gan, Huang, Yuxian, Guo, Haitao, Wang, Bin, Zhang, Jiming
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.04.2019; Public Library of Science (PLoS)
• Subjects: Adult; Antigens; Antiviral agents; Biology and Life Sciences; Cancer; Care and treatment; CD4 antigen; CD8 antigen; Cell Proliferation; Chronic infection; Clinical medicine; Cytokines; Cytokines - metabolism; Depletion; Development and progression; Dioxygenase; Education; Expansion; Female; Funding; Genomes; Hepatitis; Hepatitis B; Hepatitis B e antigen; Hepatitis B e Antigens - immunology; Hepatitis B e Antigens - metabolism; Hepatitis B virus; Hepatitis B virus - immunology; Hepatitis B, Chronic - immunology; Hepatitis B, Chronic - metabolism; Hepatitis B, Chronic - virology; Hepatology; Hospitals; Humans; IL-1β; Immune Tolerance - immunology; Immunological tolerance; Immunology; Immunotherapy; Infection; Infections; Infectious diseases; Inflammation; Interferon; Interferon-gamma - metabolism; Interleukin 6; Laboratories; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - virology; Lymphocyte Activation; Lymphocytes; Lymphocytes T; Male; Medical research; Medicine; Medicine and Health Sciences; Monocytes; Myeloid-Derived Suppressor Cells - immunology; Myeloid-Derived Suppressor Cells - metabolism; Myeloid-Derived Suppressor Cells - virology; Peripheral blood mononuclear cells; Persistent infection; Research and Analysis Methods; Risk factors; Software; Supervision; Suppressor cells; T cells; T-Lymphocytes - immunology; T-Lymphocytes, Regulatory - immunology; Transgenic animals; Virology; Virus diseases; Viruses; γ-Interferon; Indiana; United States > US; China; Indianapolis Indiana

Chronic hepatitis B virus (HBV) infection is associated with functionally impaired virus-specific T cell responses. Although the myeloid-derived suppressor cells (MDSCs) are known to play a critical role in impairing antiviral T cell responses, viral factors responsible for the expansion of MDSCs in...