Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of r...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 12; no. 1; p. 5596
Main Authors Heestermans, Marco, Naudin, Clément, Mailer, Reiner K., Konrath, Sandra, Klaetschke, Kristin, Jämsä, Anne, Frye, Maike, Deppermann, Carsten, Pula, Giordano, Kuta, Piotr, Friese, Manuel A., Gelderblom, Mathias, Sickmann, Albert, Preston, Roger J. S., Nofer, Jerzy-Roch, Rose-John, Stefan, Butler, Lynn M., Salomon, Ophira, Stavrou, Evi X., Renné, Thomas
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 22.09.2021
Nature Publishing Group
MDPI
Nature Portfolio
Subjects
13/56
13/95
14/1
631/92/612/1221
64/60
692/53/2421
692/699/75/593/567
82/80
Antibodies
Blood clots
Blood coagulation
Clinical medical disciplines: 750
Clotting
Coagulation
Coagulation factor XII
Coagulation factors
Diagnostic systems
Epidermal growth factor
Hematologi: 775
Hematology: 775
Humanities and Social Sciences
Kallikrein
Klinisk medisinske fag: 750
Medical disciplines: 700
Medicin och hälsovetenskap
Medicine
Medisinske Fag: 700
Molecular weight
multidisciplinary
Mutants
Peptides
Plasma
Plasma kallikrein
Plasmin
Reagents
Residues
Science
Science (multidisciplinary)
Standardization
Thrombin
Thromboplastin
Thrombosis
VDP
Online AccessGet full text

Cover

Abstract Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of recombinant FXII mutants identified a continuous stretch of residues Gln317–Ser339 that was essential for FXII surface binding and activation, thrombin generation and coagulation. Peptides spanning these 23 residues competed with surface-induced FXII activation. Although FXII mutants lacking residues Gln317–Ser339 were susceptible to activation by plasmin and plasma kallikrein, they were ineffective in supporting arterial and venous thrombus formation in mice. Antibodies raised against the Gln317–Ser339 region induced FXII activation and triggered controllable contact activation in solution leading to thrombin generation by the intrinsic pathway of coagulation. The antibody-activated aPTT allows for standardization of particulate aPTT reagents and for sensitive monitoring of coagulation factors VIII, IX, XI. Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.
AbstractList Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of recombinant FXII mutants identified a continuous stretch of residues Gln317–Ser339 that was essential for FXII surface binding and activation, thrombin generation and coagulation. Peptides spanning these 23 residues competed with surface-induced FXII activation. Although FXII mutants lacking residues Gln317–Ser339 were susceptible to activation by plasmin and plasma kallikrein, they were ineffective in supporting arterial and venous thrombus formation in mice. Antibodies raised against the Gln317–Ser339 region induced FXII activation and triggered controllable contact activation in solution leading to thrombin generation by the intrinsic pathway of coagulation. The antibody-activated aPTT allows for standardization of particulate aPTT reagents and for sensitive monitoring of coagulation factors VIII, IX, XI. Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of recombinant FXII mutants identified a continuous stretch of residues Gln317–Ser339 that was essential for FXII surface binding and activation, thrombin generation and coagulation. Peptides spanning these 23 residues competed with surface-induced FXII activation. Although FXII mutants lacking residues Gln317–Ser339 were susceptible to activation by plasmin and plasma kallikrein, they were ineffective in supporting arterial and venous thrombus formation in mice. Antibodies raised against the Gln317–Ser339 region induced FXII activation and triggered controllable contact activation in solution leading to thrombin generation by the intrinsic pathway of coagulation. The antibody-activated aPTT allows for standardization of particulate aPTT reagents and for sensitive monitoring of coagulation factors VIII, IX, XI.
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of recombinant FXII mutants identified a continuous stretch of residues Gln317–Ser339 that was essential for FXII surface binding and activation, thrombin generation and coagulation. Peptides spanning these 23 residues competed with surface-induced FXII activation. Although FXII mutants lacking residues Gln317–Ser339 were susceptible to activation by plasmin and plasma kallikrein, they were ineffective in supporting arterial and venous thrombus formation in mice. Antibodies raised against the Gln317–Ser339 region induced FXII activation and triggered controllable contact activation in solution leading to thrombin generation by the intrinsic pathway of coagulation. The antibody-activated aPTT allows for standardization of particulate aPTT reagents and for sensitive monitoring of coagulation factors VIII, IX, XI.Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.
Abstract Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of recombinant FXII mutants identified a continuous stretch of residues Gln317–Ser339 that was essential for FXII surface binding and activation, thrombin generation and coagulation. Peptides spanning these 23 residues competed with surface-induced FXII activation. Although FXII mutants lacking residues Gln317–Ser339 were susceptible to activation by plasmin and plasma kallikrein, they were ineffective in supporting arterial and venous thrombus formation in mice. Antibodies raised against the Gln317–Ser339 region induced FXII activation and triggered controllable contact activation in solution leading to thrombin generation by the intrinsic pathway of coagulation. The antibody-activated aPTT allows for standardization of particulate aPTT reagents and for sensitive monitoring of coagulation factors VIII, IX, XI.
ArticleNumber 5596
Author Naudin, Clément
Kuta, Piotr
Butler, Lynn M.
Preston, Roger J. S.
Renné, Thomas
Nofer, Jerzy-Roch
Klaetschke, Kristin
Frye, Maike
Gelderblom, Mathias
Deppermann, Carsten
Pula, Giordano
Konrath, Sandra
Jämsä, Anne
Friese, Manuel A.
Sickmann, Albert
Heestermans, Marco
Mailer, Reiner K.
Stavrou, Evi X.
Rose-John, Stefan
Salomon, Ophira
Author_xml – sequence: 1
  givenname: Marco
  orcidid: 0000-0002-5788-6653
  surname: Heestermans
  fullname: Heestermans, Marco
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 2
  givenname: Clément
  orcidid: 0000-0002-6777-9587
  surname: Naudin
  fullname: Naudin, Clément
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Department of Clinical Medicine, The Arctic University of Norway, Clinical Chemistry and Coagulation Research, Department of Molecular Medicine and Surgery, Karolinska Institute
– sequence: 3
  givenname: Reiner K.
  surname: Mailer
  fullname: Mailer, Reiner K.
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 4
  givenname: Sandra
  surname: Konrath
  fullname: Konrath, Sandra
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 5
  givenname: Kristin
  surname: Klaetschke
  fullname: Klaetschke, Kristin
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 6
  givenname: Anne
  surname: Jämsä
  fullname: Jämsä, Anne
  organization: Karolinska University Hospital
– sequence: 7
  givenname: Maike
  orcidid: 0000-0002-6257-7636
  surname: Frye
  fullname: Frye, Maike
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 8
  givenname: Carsten
  surname: Deppermann
  fullname: Deppermann, Carsten
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 9
  givenname: Giordano
  surname: Pula
  fullname: Pula, Giordano
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 10
  givenname: Piotr
  surname: Kuta
  fullname: Kuta, Piotr
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 11
  givenname: Manuel A.
  orcidid: 0000-0001-6380-2420
  surname: Friese
  fullname: Friese, Manuel A.
  organization: Institute for Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf
– sequence: 12
  givenname: Mathias
  surname: Gelderblom
  fullname: Gelderblom, Mathias
  organization: Department of Neurology, University Medical Center Hamburg-Eppendorf
– sequence: 13
  givenname: Albert
  surname: Sickmann
  fullname: Sickmann, Albert
  organization: Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V
– sequence: 14
  givenname: Roger J. S.
  surname: Preston
  fullname: Preston, Roger J. S.
  organization: Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland
– sequence: 15
  givenname: Jerzy-Roch
  surname: Nofer
  fullname: Nofer, Jerzy-Roch
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
– sequence: 16
  givenname: Stefan
  orcidid: 0000-0002-7519-3279
  surname: Rose-John
  fullname: Rose-John, Stefan
  organization: Institute of Biochemistry, University of Kiel
– sequence: 17
  givenname: Lynn M.
  surname: Butler
  fullname: Butler, Lynn M.
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Department of Clinical Medicine, The Arctic University of Norway, Clinical Chemistry and Coagulation Research, Department of Molecular Medicine and Surgery, Karolinska Institute
– sequence: 18
  givenname: Ophira
  surname: Salomon
  fullname: Salomon, Ophira
  organization: Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel and Sackler Faculty of Medicine, University of Tel Aviv
– sequence: 19
  givenname: Evi X.
  orcidid: 0000-0002-6075-7609
  surname: Stavrou
  fullname: Stavrou, Evi X.
  organization: Department of Medicine, Louis Stokes Veterans Administration Medical Center, Department of Medicine, Hematology and Oncology Division, Case Western Reserve University School of Medicine
– sequence: 20
  givenname: Thomas
  orcidid: 0000-0003-4594-5975
  surname: Renné
  fullname: Renné, Thomas
  email: thomas@renne.net
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center
BackLink http://kipublications.ki.se/Default.aspx?queryparsed=id:147695125$$DView record from Swedish Publication Index
BookMark eNp9kkuP0zAQxyO0iF2W_QJciMSFS8DvOBcktOJRaSUuIHGzbGfSdUntYqdFfHsmTXmUA5ZGfv3m77_G87i6iClCVT2l5CUlXL8qggrVNoTRhkmtddM-qK4YEbShLeMXf60vq5tSNgQH76gW4lF1yYWUjGh1VblVD3EKQ_B2CinWaaine6gH66eU6y-rVe1TnHBXY4TDApUwQQ3RuhFKXSDiPhwASbvejwvSB7uOqUzBlyfVw8GOBW5O83X1-d3bT7cfmruP71e3b-4aLzs6NY46IToplHZeom8YbMcV9VbKoRMEpGZcclC0cyAVBdUq5RRhzDHK2UD4dbVadPtkN2aXw9bmHybZYI4HKa-NzWhoBMO4FmzomNOUCd8LrTiQ3jEmBdYWFGp1i1b5Dru9O1Pb5dSb0_nXMIcpYKhoVScpk5j7eslFYAu9x_pmO55LnN3EcG_W6WC0kFroWeDZIuBzwApGE1O2huL_tehckdnei9MTOX3bQ5nMNhQP42gjpH0xTLZSc63bDtHn_6CbtM8RP-JIUUXQOVLs15OplAzDb7uUmLnfzNJvBvvNHPvNzEn8VCSE4xryH-n_ZP0E2wHXDg
CitedBy_id crossref_primary_10_1042_CS20220208
crossref_primary_10_1055_s_0043_1761488
crossref_primary_10_1016_j_ijbiomac_2024_130771
crossref_primary_10_1055_a_1717_7958
crossref_primary_10_1152_ajpcell_00269_2022
crossref_primary_10_1016_j_jconrel_2024_02_034
crossref_primary_10_1016_j_memsci_2023_121866
crossref_primary_10_1039_D3NR02593D
crossref_primary_10_1182_bloodadvances_2021005976
crossref_primary_10_1055_s_0043_57034
crossref_primary_10_3389_fcvm_2022_1008410
crossref_primary_10_1055_a_1951_1777
crossref_primary_10_1097_MOH_0000000000000727
crossref_primary_10_1016_j_bbamcr_2021_119166
crossref_primary_10_3389_fbioe_2023_1163405
crossref_primary_10_1111_jth_15722
crossref_primary_10_3390_jcdd9110397
crossref_primary_10_1016_j_jtha_2023_01_032
crossref_primary_10_1186_s40729_023_00503_0
crossref_primary_10_1021_acschembio_2c00538
crossref_primary_10_1055_s_0043_1769509
Cites_doi 10.1186/s13023-020-01564-9
10.1016/S0021-9258(18)60491-0
10.3389/fimmu.2019.02011
10.1182/blood-2013-12-540872
10.1182/blood-2015-01-622811
10.1182/blood-2016-02-699561
10.1038/ncomms12616
10.1055/s-0039-3402760
10.1086/509899
10.1083/jcb.200709181
10.1084/jem.20052458
10.1182/blood.V92.11.4198
10.1111/ijlh.12658
10.1161/ATVBAHA.116.308595
10.1016/j.colsurfb.2018.11.066
10.1016/j.bcmd.2005.12.014
10.1126/scitranslmed.3006804
10.1074/jbc.271.22.13040
10.1097/MOH.0000000000000367
10.1182/blood-2016-10-744110
10.1038/207422a0
10.1038/sj.gt.3300947
10.1111/j.1432-1033.1992.tb17155.x
10.1074/jbc.271.22.13061
10.1182/blood.V65.5.1263.1263
10.1111/j.1432-1033.1996.0240q.x
10.1182/blood-2014-05-577932
10.1161/ATVBAHA.118.311193
10.1182/blood-2014-01-550285
10.1084/jem.20050664
10.1182/blood-2016-09-692996
10.1182/blood.V86.11.4134.bloodjournal86114134
10.1161/CIRCRESAHA.118.313155
10.1111/j.1538-7836.2011.04280.x
10.1080/17474086.2016.1191944
10.1016/j.cell.2009.11.001
10.1016/S0021-9258(18)51578-7
10.1309/AJCP3J1ZKYBFQXJM
10.1182/blood-2018-06-860270
10.1161/CIRCRESAHA.115.306841
10.1309/4WK2-99F2-VEMB-15YJ
10.1182/blood-2016-08-734988
10.1055/s-0039-1678719
10.1016/j.ebiom.2021.103382
10.1590/1414-431x20187813
10.1074/jbc.RA119.009788
10.3389/fimmu.2017.01115
10.1016/j.clim.2011.07.002
10.1016/S0021-9258(18)61089-0
10.1182/blood-2010-01-266791
10.1016/j.clim.2013.08.001
10.1016/j.bbrc.2006.03.092
10.1161/CIRCULATIONAHA.109.924761
10.1055/s-0037-1614171
10.1111/hae.12402
10.1172/JCI108741
10.1172/JCI77139
10.1042/bj2970249
10.1016/j.thromres.2016.02.020
10.1182/blood.2019004617
10.1074/jbc.M105221200
10.1055/s-0036-1598003
10.1126/science.aam8897
10.1016/j.bbamcr.2017.07.009
10.1016/j.blre.2018.04.001
10.1160/TH04-04-0250
10.1182/blood-2017-04-569111
10.1111/jth.13235
10.1055/a-1336-0526
10.1007/BF02871828
ContentType Journal Article
Copyright The Author(s) 2021
The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
info:eu-repo/semantics/openAccess
Copyright_xml – notice: The Author(s) 2021
– notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: info:eu-repo/semantics/openAccess
DBID C6C
AAYXX
CITATION
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PIMPY
PQEST
PQQKQ
PQUKI
RC3
SOI
7X8
3HK
5PM
ADTPV
AOWAS
D8T
ZZAVC
DOA
DOI 10.1038/s41467-021-25888-7
DatabaseName SpringerOpen
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
ProQuest_Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
Advanced Technologies & Aerospace Database‎ (1962 - current)
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
NORA - Norwegian Open Research Archives
PubMed Central (Full Participant titles)
SwePub
SwePub Articles
SWEPUB Freely available online
SwePub Articles full text
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Technology Collection
Technology Research Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList


Publicly Available Content Database

CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: SpringerOpen
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: Open Access: DOAJ - Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Medicine
EISSN 2041-1723
EndPage 5596
ExternalDocumentID oai_doaj_org_article_23842f92b8124cd4863e0db2254038e6
oai_prod_swepub_kib_ki_se_147695125
10037_23606
10_1038_s41467_021_25888_7
GrantInformation_xml – fundername: Deutsche Forschungsgemeinschaft (German Research Foundation)
  grantid: A11/SFB 877; B8/SFB 841; P6/KFO 306
  funderid: https://doi.org/10.13039/501100001659
– fundername: ;
  grantid: A11/SFB 877; B8/SFB 841; P6/KFO 306
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADRAZ
AENEX
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AAYXX
CITATION
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PQEST
PQUKI
RC3
SOI
7X8
3HK
4.4
AAPBV
AAYJO
ABAWZ
ADQMX
AEDAW
BAPOH
CAG
COF
EJD
ZA5
5PM
ADTPV
AOWAS
D8T
LGEZI
LOTEE
NADUK
NXXTH
ZZAVC
ID FETCH-LOGICAL-c591t-b1b4495468bc5172efa9361ca55f940e582353e619be561e6766b6022b2132f03
IEDL.DBID RPM
ISSN 2041-1723
IngestDate Tue Oct 22 15:16:17 EDT 2024
Wed Oct 30 05:04:30 EDT 2024
Tue Sep 17 21:18:43 EDT 2024
Sat Apr 29 05:44:21 EDT 2023
Tue Aug 27 04:36:31 EDT 2024
Wed Oct 23 03:30:55 EDT 2024
Fri Aug 23 01:13:31 EDT 2024
Fri Oct 11 20:51:33 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c591t-b1b4495468bc5172efa9361ca55f940e582353e619be561e6766b6022b2132f03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Nature Communications
ORCID 0000-0001-6380-2420
0000-0002-6777-9587
0000-0002-6075-7609
0000-0002-5788-6653
0000-0002-7519-3279
0000-0002-6257-7636
0000-0003-4594-5975
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458485/
PMID 34552086
PQID 2575160147
PQPubID 546298
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_23842f92b8124cd4863e0db2254038e6
swepub_primary_oai_prod_swepub_kib_ki_se_147695125
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8458485
cristin_nora_10037_23606
proquest_miscellaneous_2575838879
proquest_journals_2575160147
crossref_primary_10_1038_s41467_021_25888_7
springer_journals_10_1038_s41467_021_25888_7
PublicationCentury 2000
PublicationDate 2021-09-22
PublicationDateYYYYMMDD 2021-09-22
PublicationDate_xml – month: 09
  year: 2021
  text: 2021-09-22
  day: 22
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationYear 2021
Publisher Nature Publishing Group UK
Nature Publishing Group
MDPI
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: MDPI
– name: Nature Portfolio
References Pauer (CR63) 2004; 92
Wheeler, Gailani (CR60) 2016; 9
Herwald, Dedio, Kellner, Loos, Muller-Esterl (CR62) 1996; 271
Chan, Weitz (CR11) 2019; 124
Citarella, Fedele, Roem, Fantoni, Hack (CR42) 1998; 92
Hagedorn (CR6) 2010; 121
Revak, Cochrane, Griffin (CR22) 1977; 59
Clarke (CR41) 1989; 264
Fredenburgh, Gross, Weitz (CR21) 2017; 129
Citarella (CR47) 1996; 238
Verhoef (CR17) 2017; 129
Clark (CR34) 2020; 120
Travers, Shenoi, Kalathottukaren, Kizhakkedathu, Morrissey (CR29) 2014; 124
Kokoye (CR31) 2016; 140
Maas, Renne (CR4) 2018; 131
Naudin, Burillo, Blankenberg, Butler, Renne (CR2) 2017; 43
Tillman, Gruber, McCarty, Gailani (CR10) 2018; 32
Renne, Nieswandt, Gailani (CR3) 2006; 36
Kilinc (CR23) 2011; 9
Kleinschnitz (CR66) 2006; 203
Bickmann, Baglin, Meijers, Renne (CR12) 2017; 24
Weidmann (CR20) 2017; 1864
Zilberman-Rudenko (CR26) 2018; 38
Labberton (CR28) 2016; 7
Favaloro, Kershaw, Mohammed, Lippi (CR57) 2019; 45
Ivanov (CR27) 2019; 133
Contreras-Garcia (CR36) 2019; 175
Bjorkqvist (CR51) 2015; 125
Citarella, te Velthuis, Helmer-Citterich, Hack (CR43) 2000; 84
Muller (CR25) 2009; 139
López-Gálvez (CR53) 2020; 15
van den Besselaar (CR15) 1989; 19
Nuijens (CR44) 1989; 264
Williamson (CR56) 1994; 297
CR16
Larsson (CR7) 2014; 6
Hofman (CR46) 2020; 295
Cichon (CR49) 2006; 79
Renne, Stavrou (CR5) 2019; 10
Fritsma (CR13) 2012; 137
Kiss (CR55) 2013; 149
Nickel (CR24) 2015; 126
Fragnan (CR52) 2018; 51
Liu, Song, Liu (CR64) 1999; 6
Nickel, Long, Fuchs, Butler, Renne (CR9) 2017; 37
Wijeyewickrema (CR18) 2016; 128
Wendelboe, Raskob (CR1) 2016; 118
Renne (CR30) 2005; 202
Englert (CR69) 2021; 67
Renne, Gailani, Meijers, Muller-Esterl (CR70) 2002; 277
Smith (CR35) 2010; 116
Ivanov (CR38) 2017; 129
James, Salomon, Mikovic, Peyvandi (CR59) 2014; 20
Jimenez-Alcazar (CR65) 2017; 358
Brigden, Johnston (CR14) 2000; 114
Bender, Weidmann, Rose-John, Renne, Long (CR37) 2017; 8
Ravon, Citarella, Lubbers, Pascucci, Hack (CR45) 1995; 86
Citarella (CR48) 1992; 208
Benz (CR68) 2008; 180
Bork (CR54) 2011; 141
Dewald, Bork (CR50) 2006; 343
Yau (CR19) 2014; 123
Adcock, Gosselin (CR58) 2017; 39
Pixley, Stumpo, Birkmeyer, Silver, Colman (CR40) 1987; 262
Long, Kenne, Jung, Fuchs, Renne (CR8) 2016; 14
Stavrou (CR32) 2015; 125
Saito, Ishihara, Suzuki, Watanabe (CR39) 1985; 65
Castaldi, Larrieu, Caen (CR33) 1965; 207
Mailer (CR67) 2021; 137
Herwald (CR61) 1996; 271
ML Brigden (25888_CR14) 2000; 114
J Bjorkqvist (25888_CR51) 2015; 125
JJ Verhoef (25888_CR17) 2017; 129
RA Pixley (25888_CR40) 1987; 262
A Contreras-Garcia (25888_CR36) 2019; 175
C Naudin (25888_CR2) 2017; 43
PM Benz (25888_CR68) 2008; 180
AT Long (25888_CR8) 2016; 14
C Kleinschnitz (25888_CR66) 2006; 203
H Englert (25888_CR69) 2021; 67
AM Wendelboe (25888_CR1) 2016; 118
E Kilinc (25888_CR23) 2011; 9
F Citarella (25888_CR43) 2000; 84
I Hagedorn (25888_CR6) 2010; 121
H Herwald (25888_CR61) 1996; 271
R López-Gálvez (25888_CR53) 2020; 15
I Ivanov (25888_CR27) 2019; 133
SA Smith (25888_CR35) 2010; 116
EJ Favaloro (25888_CR57) 2019; 45
KF Nickel (25888_CR24) 2015; 126
KF Nickel (25888_CR9) 2017; 37
LC Wijeyewickrema (25888_CR18) 2016; 128
K Bork (25888_CR54) 2011; 141
JC Fredenburgh (25888_CR21) 2017; 129
ZLM Hofman (25888_CR46) 2020; 295
25888_CR16
RJ Travers (25888_CR29) 2014; 124
AM van den Besselaar (25888_CR15) 1989; 19
H Weidmann (25888_CR20) 2017; 1864
I Ivanov (25888_CR38) 2017; 129
F Citarella (25888_CR47) 1996; 238
HU Pauer (25888_CR63) 2004; 92
C Maas (25888_CR4) 2018; 131
PA Castaldi (25888_CR33) 1965; 207
G Dewald (25888_CR50) 2006; 343
JK Bickmann (25888_CR12) 2017; 24
L Labberton (25888_CR28) 2016; 7
EX Stavrou (25888_CR32) 2015; 125
JW Yau (25888_CR19) 2014; 123
NC Chan (25888_CR11) 2019; 124
H Herwald (25888_CR62) 1996; 271
SD Revak (25888_CR22) 1977; 59
MP Williamson (25888_CR56) 1994; 297
T Renne (25888_CR3) 2006; 36
F Muller (25888_CR25) 2009; 139
H Saito (25888_CR39) 1985; 65
F Citarella (25888_CR42) 1998; 92
F Liu (25888_CR64) 1999; 6
AP Wheeler (25888_CR60) 2016; 9
BF Tillman (25888_CR10) 2018; 32
T Renne (25888_CR30) 2005; 202
DM Ravon (25888_CR45) 1995; 86
RK Mailer (25888_CR67) 2021; 137
S Cichon (25888_CR49) 2006; 79
P James (25888_CR59) 2014; 20
M Larsson (25888_CR7) 2014; 6
T Renne (25888_CR5) 2019; 10
L Bender (25888_CR37) 2017; 8
N Fragnan (25888_CR52) 2018; 51
T Renne (25888_CR70) 2002; 277
CC Clark (25888_CR34) 2020; 120
BJ Clarke (25888_CR41) 1989; 264
JH Nuijens (25888_CR44) 1989; 264
N Kiss (25888_CR55) 2013; 149
F Citarella (25888_CR48) 1992; 208
DM Adcock (25888_CR58) 2017; 39
M Jimenez-Alcazar (25888_CR65) 2017; 358
GA Fritsma (25888_CR13) 2012; 137
J Zilberman-Rudenko (25888_CR26) 2018; 38
Y Kokoye (25888_CR31) 2016; 140
References_xml – volume: 15
  year: 2020
  ident: CR53
  article-title: Factor XII in PMM2-CDG patients: role of N-glycosylation in the secretion and function of the first element of the contact pathway
  publication-title: Orphanet J. Rare Dis.
  doi: 10.1186/s13023-020-01564-9
  contributor:
    fullname: López-Gálvez
– volume: 264
  start-page: 11497
  year: 1989
  end-page: 11502
  ident: CR41
  article-title: Mapping of a putative surface-binding site of human coagulation factor XII
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)60491-0
  contributor:
    fullname: Clarke
– volume: 10
  start-page: 2011
  year: 2019
  ident: CR5
  article-title: Roles of factor XII in innate immunity
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2019.02011
  contributor:
    fullname: Stavrou
– volume: 123
  start-page: 2102
  year: 2014
  end-page: 2107
  ident: CR19
  article-title: Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits
  publication-title: Blood
  doi: 10.1182/blood-2013-12-540872
  contributor:
    fullname: Yau
– volume: 126
  start-page: 1379
  year: 2015
  end-page: 1389
  ident: CR24
  article-title: The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis
  publication-title: Blood
  doi: 10.1182/blood-2015-01-622811
  contributor:
    fullname: Nickel
– ident: CR16
– volume: 128
  start-page: 1766
  year: 2016
  end-page: 1776
  ident: CR18
  article-title: Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor
  publication-title: Blood
  doi: 10.1182/blood-2016-02-699561
  contributor:
    fullname: Wijeyewickrema
– volume: 7
  year: 2016
  ident: CR28
  article-title: Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12616
  contributor:
    fullname: Labberton
– volume: 120
  start-page: 400
  year: 2020
  end-page: 411
  ident: CR34
  article-title: The fibronectin type II domain of factor XII ensures zymogen quiescence
  publication-title: Thromb. Haemost.
  doi: 10.1055/s-0039-3402760
  contributor:
    fullname: Clark
– volume: 79
  start-page: 1098
  year: 2006
  end-page: 1104
  ident: CR49
  article-title: Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/509899
  contributor:
    fullname: Cichon
– volume: 180
  start-page: 205
  year: 2008
  end-page: 219
  ident: CR68
  article-title: Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200709181
  contributor:
    fullname: Benz
– volume: 203
  start-page: 513
  year: 2006
  end-page: 518
  ident: CR66
  article-title: Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20052458
  contributor:
    fullname: Kleinschnitz
– volume: 92
  start-page: 4198
  year: 1998
  end-page: 4206
  ident: CR42
  article-title: The second exon-encoded factor XII region is involved in the interaction of factor XII with factor XI and does not contribute to the binding site for negatively charged surfaces
  publication-title: Blood
  doi: 10.1182/blood.V92.11.4198
  contributor:
    fullname: Hack
– volume: 39
  start-page: 37
  year: 2017
  end-page: 40
  ident: CR58
  article-title: The danger of relying on the APTT and PT in patients on DOAC therapy, a potential patient safety issue
  publication-title: Int J. Lab Hemat.
  doi: 10.1111/ijlh.12658
  contributor:
    fullname: Gosselin
– volume: 37
  start-page: 13
  year: 2017
  end-page: 20
  ident: CR9
  article-title: Factor XII as a therapeutic target in thromboembolic and inflammatory diseases
  publication-title: Arterioscl Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.116.308595
  contributor:
    fullname: Renne
– volume: 19
  start-page: 371
  year: 1989
  end-page: 377
  ident: CR15
  article-title: Standardization of the activated partial thromboplastin time for monitoring of heparin therapy: where should we go?
  publication-title: Ric. Clin. Lab
  contributor:
    fullname: van den Besselaar
– volume: 175
  start-page: 596
  year: 2019
  end-page: 605
  ident: CR36
  article-title: Synthetic anionic surfaces can replace microparticles in stimulating burst coagulation of blood plasma
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2018.11.066
  contributor:
    fullname: Contreras-Garcia
– volume: 36
  start-page: 148
  year: 2006
  end-page: 151
  ident: CR3
  article-title: The intrinsic pathway of coagulation is essential for thrombus stability in mice
  publication-title: Blood Cells Mol. Dis.
  doi: 10.1016/j.bcmd.2005.12.014
  contributor:
    fullname: Gailani
– volume: 6
  start-page: 222ra217
  year: 2014
  ident: CR7
  article-title: A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3006804
  contributor:
    fullname: Larsson
– volume: 271
  start-page: 13040
  year: 1996
  end-page: 13047
  ident: CR62
  article-title: Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.22.13040
  contributor:
    fullname: Muller-Esterl
– volume: 24
  start-page: 419
  year: 2017
  end-page: 426
  ident: CR12
  article-title: Novel targets for anticoagulants lacking bleeding risk
  publication-title: Curr. Opin. Hematol.
  doi: 10.1097/MOH.0000000000000367
  contributor:
    fullname: Renne
– volume: 129
  start-page: 1527
  year: 2017
  end-page: 1537
  ident: CR38
  article-title: Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation
  publication-title: Blood
  doi: 10.1182/blood-2016-10-744110
  contributor:
    fullname: Ivanov
– volume: 207
  start-page: 422
  year: 1965
  end-page: 424
  ident: CR33
  article-title: Availability of platelet Factor 3 and activation of factor XII in thrombasthenia
  publication-title: Nature
  doi: 10.1038/207422a0
  contributor:
    fullname: Caen
– volume: 6
  start-page: 1258
  year: 1999
  end-page: 1266
  ident: CR64
  article-title: Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
  publication-title: Gene Ther.
  doi: 10.1038/sj.gt.3300947
  contributor:
    fullname: Liu
– volume: 208
  start-page: 23
  year: 1992
  end-page: 30
  ident: CR48
  article-title: Control of human coagulation by recombinant serine proteases. Blood clotting is activated by recombinant factor XII deleted of five regulatory domains
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1992.tb17155.x
  contributor:
    fullname: Citarella
– volume: 271
  start-page: 13061
  year: 1996
  end-page: 13067
  ident: CR61
  article-title: Mapping of the discontinuous kininogen binding site of prekallikrein. A distal binding segment is located in the heavy chain domain A4
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.22.13061
  contributor:
    fullname: Herwald
– volume: 65
  start-page: 1263
  year: 1985
  end-page: 1268
  ident: CR39
  article-title: Production and characterization of a murine monoclonal antibody against a heavy chain of Hageman factor (factor XII)
  publication-title: Blood
  doi: 10.1182/blood.V65.5.1263.1263
  contributor:
    fullname: Watanabe
– volume: 238
  start-page: 240
  year: 1996
  end-page: 249
  ident: CR47
  article-title: Structure/function analysis of human factor XII using recombinant deletion mutants. Evidence for an additional region involved in the binding to negatively charged surfaces
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1996.0240q.x
  contributor:
    fullname: Citarella
– volume: 124
  start-page: 3183
  year: 2014
  end-page: 3190
  ident: CR29
  article-title: Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis
  publication-title: Blood
  doi: 10.1182/blood-2014-05-577932
  contributor:
    fullname: Morrissey
– volume: 38
  start-page: 1748
  year: 2018
  end-page: 1760
  ident: CR26
  article-title: Factor XII activation promotes platelet consumption in the presence of bacterial-type long-chain polyphosphate in vitro and in vivo
  publication-title: Arterioscl Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.311193
  contributor:
    fullname: Zilberman-Rudenko
– volume: 125
  start-page: 710
  year: 2015
  end-page: 719
  ident: CR32
  article-title: Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor
  publication-title: Blood
  doi: 10.1182/blood-2014-01-550285
  contributor:
    fullname: Stavrou
– volume: 202
  start-page: 271
  year: 2005
  end-page: 281
  ident: CR30
  article-title: Defective thrombus formation in mice lacking coagulation factor XII
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20050664
  contributor:
    fullname: Renne
– volume: 129
  start-page: 147
  year: 2017
  end-page: 154
  ident: CR21
  article-title: Emerging anticoagulant strategies
  publication-title: Blood
  doi: 10.1182/blood-2016-09-692996
  contributor:
    fullname: Weitz
– volume: 86
  start-page: 4134
  year: 1995
  end-page: 4143
  ident: CR45
  article-title: Monoclonal antibody F1 binds to the kringle domain of factor XII and induces enhanced susceptibility for cleavage by kallikrein
  publication-title: Blood
  doi: 10.1182/blood.V86.11.4134.bloodjournal86114134
  contributor:
    fullname: Hack
– volume: 124
  start-page: 426
  year: 2019
  end-page: 436
  ident: CR11
  article-title: Antithrombotic agents
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.118.313155
  contributor:
    fullname: Weitz
– volume: 9
  start-page: 1359
  year: 2011
  end-page: 1367
  ident: CR23
  article-title: Factor XII activation is essential to sustain the procoagulant effects of particulate matter
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2011.04280.x
  contributor:
    fullname: Kilinc
– volume: 9
  start-page: 629
  year: 2016
  end-page: 637
  ident: CR60
  article-title: Why factor XI deficiency is a clinical concern
  publication-title: Expert Rev. Hematol.
  doi: 10.1080/17474086.2016.1191944
  contributor:
    fullname: Gailani
– volume: 139
  start-page: 1143
  year: 2009
  end-page: 1156
  ident: CR25
  article-title: Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
  publication-title: Cell
  doi: 10.1016/j.cell.2009.11.001
  contributor:
    fullname: Muller
– volume: 264
  start-page: 12941
  year: 1989
  end-page: 12949
  ident: CR44
  article-title: Activation of the contact system of coagulation by a monoclonal antibody directed against a neodeterminant in the heavy chain region of human coagulation factor XII (Hageman factor)
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)51578-7
  contributor:
    fullname: Nuijens
– volume: 137
  start-page: 904
  year: 2012
  end-page: 908
  ident: CR13
  article-title: Recommendations for appropriate activated partial thromboplastin time reagent selection and utilization
  publication-title: Am. J. Clin. Pathol.
  doi: 10.1309/AJCP3J1ZKYBFQXJM
  contributor:
    fullname: Fritsma
– volume: 133
  start-page: 1152
  year: 2019
  end-page: 1163
  ident: CR27
  article-title: A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain
  publication-title: Blood
  doi: 10.1182/blood-2018-06-860270
  contributor:
    fullname: Ivanov
– volume: 118
  start-page: 1340
  year: 2016
  end-page: 1347
  ident: CR1
  article-title: Global burden of thrombosis: epidemiologic aspects
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.115.306841
  contributor:
    fullname: Raskob
– volume: 114
  start-page: 276
  year: 2000
  end-page: 282
  ident: CR14
  article-title: A survey of aPTT reporting in Canadian medical laboratories. The need for increased standardization. Thrombosis Interest Group of Canada
  publication-title: Am. J. Clin. Pathol.
  doi: 10.1309/4WK2-99F2-VEMB-15YJ
  contributor:
    fullname: Johnston
– volume: 129
  start-page: 1707
  year: 2017
  end-page: 1717
  ident: CR17
  article-title: Polyphosphate nanoparticles on the platelet surface trigger contact system activation
  publication-title: Blood
  doi: 10.1182/blood-2016-08-734988
  contributor:
    fullname: Verhoef
– volume: 45
  start-page: 22
  year: 2019
  end-page: 35
  ident: CR57
  article-title: How to optimize activated partial thromboplastin time (APTT) testing: solutions to establishing and verifying normal reference intervals and assessing APTT reagents for sensitivity to heparin, lupus anticoagulant, and clotting factors
  publication-title: Sem. Thromb. Hemost.
  doi: 10.1055/s-0039-1678719
  contributor:
    fullname: Lippi
– volume: 67
  start-page: 103382
  year: 2021
  ident: CR69
  article-title: Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2021.103382
  contributor:
    fullname: Englert
– volume: 51
  start-page: e7813
  year: 2018
  ident: CR52
  article-title: Hereditary angioedema with C1 inhibitor (C1-INH) deficit: the strength of recognition (51 cases)
  publication-title: Braz. J. Med. Biol. Res.
  doi: 10.1590/1414-431x20187813
  contributor:
    fullname: Fragnan
– volume: 295
  start-page: 363
  year: 2020
  end-page: 374
  ident: CR46
  article-title: A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA119.009788
  contributor:
    fullname: Hofman
– volume: 8
  start-page: 1115
  year: 2017
  ident: CR37
  article-title: Factor XII-driven inflammatory reactions with implications for anaphylaxis
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.01115
  contributor:
    fullname: Long
– volume: 141
  start-page: 31
  year: 2011
  end-page: 35
  ident: CR54
  article-title: A novel mutation in the coagulation factor 12 gene in subjects with hereditary angioedema and normal C1-inhibitor
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2011.07.002
  contributor:
    fullname: Bork
– volume: 262
  start-page: 10140
  year: 1987
  end-page: 10145
  ident: CR40
  article-title: A monoclonal antibody recognizing an icosapeptide sequence in the heavy chain of human factor XII inhibits surface-catalyzed activation
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)61089-0
  contributor:
    fullname: Colman
– volume: 116
  start-page: 4353
  year: 2010
  end-page: 4359
  ident: CR35
  article-title: Polyphosphate exerts differential effects on blood clotting, depending on polymer size
  publication-title: Blood
  doi: 10.1182/blood-2010-01-266791
  contributor:
    fullname: Smith
– volume: 149
  start-page: 142
  year: 2013
  end-page: 145
  ident: CR55
  article-title: Novel duplication in the F12 gene in a patient with recurrent angioedema
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2013.08.001
  contributor:
    fullname: Kiss
– volume: 343
  start-page: 1286
  year: 2006
  end-page: 1289
  ident: CR50
  article-title: Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2006.03.092
  contributor:
    fullname: Bork
– volume: 121
  start-page: 1510
  year: 2010
  end-page: 1517
  ident: CR6
  article-title: Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.109.924761
  contributor:
    fullname: Hagedorn
– volume: 84
  start-page: 1057
  year: 2000
  end-page: 1065
  ident: CR43
  article-title: Identification of a putative binding site for negatively charged surfaces in the fibronectin type II domain of human factor XII–an immunochemical and homology modeling approach
  publication-title: Thromb. Haemost.
  doi: 10.1055/s-0037-1614171
  contributor:
    fullname: Hack
– volume: 20
  start-page: 71
  year: 2014
  end-page: 75
  ident: CR59
  article-title: Rare bleeding disorders - bleeding assessment tools, laboratory aspects and phenotype and therapy of FXI deficiency
  publication-title: Haemophilia
  doi: 10.1111/hae.12402
  contributor:
    fullname: Peyvandi
– volume: 59
  start-page: 1167
  year: 1977
  end-page: 1175
  ident: CR22
  article-title: The binding and cleavage characteristics of human Hageman factor during contact activation. A comparison of normal plasma with plasmas deficient in factor XI, prekallikrein, or high molecular weight kininogen
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI108741
  contributor:
    fullname: Griffin
– volume: 125
  start-page: 3132
  year: 2015
  end-page: 3146
  ident: CR51
  article-title: Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI77139
  contributor:
    fullname: Bjorkqvist
– volume: 297
  start-page: 249
  year: 1994
  end-page: 260
  ident: CR56
  article-title: The structure and function of proline-rich regions in proteins
  publication-title: Biochem. J.
  doi: 10.1042/bj2970249
  contributor:
    fullname: Williamson
– volume: 140
  start-page: 118
  year: 2016
  end-page: 124
  ident: CR31
  article-title: A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation
  publication-title: Thromb. Res.
  doi: 10.1016/j.thromres.2016.02.020
  contributor:
    fullname: Kokoye
– volume: 137
  start-page: 1392
  year: 2021
  end-page: 1405
  ident: CR67
  article-title: Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
  publication-title: Blood
  doi: 10.1182/blood.2019004617
  contributor:
    fullname: Mailer
– volume: 277
  start-page: 4892
  year: 2002
  end-page: 4899
  ident: CR70
  article-title: Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M105221200
  contributor:
    fullname: Muller-Esterl
– volume: 43
  start-page: 814
  year: 2017
  end-page: 826
  ident: CR2
  article-title: Factor XII contact activation
  publication-title: Sem. Thromb. Hemost.
  doi: 10.1055/s-0036-1598003
  contributor:
    fullname: Renne
– volume: 358
  start-page: 1202
  year: 2017
  end-page: 1206
  ident: CR65
  article-title: Host DNases prevent vascular occlusion by neutrophil extracellular traps
  publication-title: Science
  doi: 10.1126/science.aam8897
  contributor:
    fullname: Jimenez-Alcazar
– volume: 1864
  start-page: 2118
  year: 2017
  end-page: 2127
  ident: CR20
  article-title: The plasma contact system, a protease cascade at the nexus of inflammation, coagulation and immunity
  publication-title: Biochim Biophys. Acta
  doi: 10.1016/j.bbamcr.2017.07.009
  contributor:
    fullname: Weidmann
– volume: 32
  start-page: 433
  year: 2018
  end-page: 448
  ident: CR10
  article-title: Plasma contact factors as therapeutic targets
  publication-title: Blood Rev.
  doi: 10.1016/j.blre.2018.04.001
  contributor:
    fullname: Gailani
– volume: 92
  start-page: 503
  year: 2004
  end-page: 508
  ident: CR63
  article-title: Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo
  publication-title: Thromb. Haemost.
  doi: 10.1160/TH04-04-0250
  contributor:
    fullname: Pauer
– volume: 131
  start-page: 1903
  year: 2018
  end-page: 1909
  ident: CR4
  article-title: Coagulation factor XII in thrombosis and inflammation
  publication-title: Blood
  doi: 10.1182/blood-2017-04-569111
  contributor:
    fullname: Renne
– volume: 14
  start-page: 427
  year: 2016
  end-page: 437
  ident: CR8
  article-title: Contact system revisited: an interface between inflammation, coagulation, and innate immunity
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/jth.13235
  contributor:
    fullname: Renne
– volume: 149
  start-page: 142
  year: 2013
  ident: 25888_CR55
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2013.08.001
  contributor:
    fullname: N Kiss
– volume: 20
  start-page: 71
  year: 2014
  ident: 25888_CR59
  publication-title: Haemophilia
  doi: 10.1111/hae.12402
  contributor:
    fullname: P James
– volume: 139
  start-page: 1143
  year: 2009
  ident: 25888_CR25
  publication-title: Cell
  doi: 10.1016/j.cell.2009.11.001
  contributor:
    fullname: F Muller
– volume: 208
  start-page: 23
  year: 1992
  ident: 25888_CR48
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1992.tb17155.x
  contributor:
    fullname: F Citarella
– volume: 124
  start-page: 426
  year: 2019
  ident: 25888_CR11
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.118.313155
  contributor:
    fullname: NC Chan
– volume: 120
  start-page: 400
  year: 2020
  ident: 25888_CR34
  publication-title: Thromb. Haemost.
  doi: 10.1055/s-0039-3402760
  contributor:
    fullname: CC Clark
– volume: 10
  start-page: 2011
  year: 2019
  ident: 25888_CR5
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2019.02011
  contributor:
    fullname: T Renne
– volume: 128
  start-page: 1766
  year: 2016
  ident: 25888_CR18
  publication-title: Blood
  doi: 10.1182/blood-2016-02-699561
  contributor:
    fullname: LC Wijeyewickrema
– volume: 38
  start-page: 1748
  year: 2018
  ident: 25888_CR26
  publication-title: Arterioscl Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.311193
  contributor:
    fullname: J Zilberman-Rudenko
– volume: 9
  start-page: 1359
  year: 2011
  ident: 25888_CR23
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2011.04280.x
  contributor:
    fullname: E Kilinc
– volume: 343
  start-page: 1286
  year: 2006
  ident: 25888_CR50
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2006.03.092
  contributor:
    fullname: G Dewald
– volume: 7
  year: 2016
  ident: 25888_CR28
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12616
  contributor:
    fullname: L Labberton
– volume: 175
  start-page: 596
  year: 2019
  ident: 25888_CR36
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2018.11.066
  contributor:
    fullname: A Contreras-Garcia
– volume: 9
  start-page: 629
  year: 2016
  ident: 25888_CR60
  publication-title: Expert Rev. Hematol.
  doi: 10.1080/17474086.2016.1191944
  contributor:
    fullname: AP Wheeler
– volume: 297
  start-page: 249
  year: 1994
  ident: 25888_CR56
  publication-title: Biochem. J.
  doi: 10.1042/bj2970249
  contributor:
    fullname: MP Williamson
– volume: 92
  start-page: 503
  year: 2004
  ident: 25888_CR63
  publication-title: Thromb. Haemost.
  doi: 10.1160/TH04-04-0250
  contributor:
    fullname: HU Pauer
– volume: 116
  start-page: 4353
  year: 2010
  ident: 25888_CR35
  publication-title: Blood
  doi: 10.1182/blood-2010-01-266791
  contributor:
    fullname: SA Smith
– volume: 358
  start-page: 1202
  year: 2017
  ident: 25888_CR65
  publication-title: Science
  doi: 10.1126/science.aam8897
  contributor:
    fullname: M Jimenez-Alcazar
– volume: 202
  start-page: 271
  year: 2005
  ident: 25888_CR30
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20050664
  contributor:
    fullname: T Renne
– volume: 124
  start-page: 3183
  year: 2014
  ident: 25888_CR29
  publication-title: Blood
  doi: 10.1182/blood-2014-05-577932
  contributor:
    fullname: RJ Travers
– volume: 65
  start-page: 1263
  year: 1985
  ident: 25888_CR39
  publication-title: Blood
  doi: 10.1182/blood.V65.5.1263.1263
  contributor:
    fullname: H Saito
– volume: 203
  start-page: 513
  year: 2006
  ident: 25888_CR66
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20052458
  contributor:
    fullname: C Kleinschnitz
– volume: 121
  start-page: 1510
  year: 2010
  ident: 25888_CR6
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.109.924761
  contributor:
    fullname: I Hagedorn
– volume: 131
  start-page: 1903
  year: 2018
  ident: 25888_CR4
  publication-title: Blood
  doi: 10.1182/blood-2017-04-569111
  contributor:
    fullname: C Maas
– volume: 126
  start-page: 1379
  year: 2015
  ident: 25888_CR24
  publication-title: Blood
  doi: 10.1182/blood-2015-01-622811
  contributor:
    fullname: KF Nickel
– volume: 207
  start-page: 422
  year: 1965
  ident: 25888_CR33
  publication-title: Nature
  doi: 10.1038/207422a0
  contributor:
    fullname: PA Castaldi
– volume: 238
  start-page: 240
  year: 1996
  ident: 25888_CR47
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1996.0240q.x
  contributor:
    fullname: F Citarella
– volume: 6
  start-page: 222ra217
  year: 2014
  ident: 25888_CR7
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3006804
  contributor:
    fullname: M Larsson
– volume: 6
  start-page: 1258
  year: 1999
  ident: 25888_CR64
  publication-title: Gene Ther.
  doi: 10.1038/sj.gt.3300947
  contributor:
    fullname: F Liu
– volume: 180
  start-page: 205
  year: 2008
  ident: 25888_CR68
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200709181
  contributor:
    fullname: PM Benz
– volume: 45
  start-page: 22
  year: 2019
  ident: 25888_CR57
  publication-title: Sem. Thromb. Hemost.
  doi: 10.1055/s-0039-1678719
  contributor:
    fullname: EJ Favaloro
– volume: 264
  start-page: 12941
  year: 1989
  ident: 25888_CR44
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)51578-7
  contributor:
    fullname: JH Nuijens
– volume: 123
  start-page: 2102
  year: 2014
  ident: 25888_CR19
  publication-title: Blood
  doi: 10.1182/blood-2013-12-540872
  contributor:
    fullname: JW Yau
– volume: 67
  start-page: 103382
  year: 2021
  ident: 25888_CR69
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2021.103382
  contributor:
    fullname: H Englert
– ident: 25888_CR16
  doi: 10.1055/a-1336-0526
– volume: 8
  start-page: 1115
  year: 2017
  ident: 25888_CR37
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.01115
  contributor:
    fullname: L Bender
– volume: 129
  start-page: 147
  year: 2017
  ident: 25888_CR21
  publication-title: Blood
  doi: 10.1182/blood-2016-09-692996
  contributor:
    fullname: JC Fredenburgh
– volume: 79
  start-page: 1098
  year: 2006
  ident: 25888_CR49
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/509899
  contributor:
    fullname: S Cichon
– volume: 262
  start-page: 10140
  year: 1987
  ident: 25888_CR40
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)61089-0
  contributor:
    fullname: RA Pixley
– volume: 277
  start-page: 4892
  year: 2002
  ident: 25888_CR70
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M105221200
  contributor:
    fullname: T Renne
– volume: 137
  start-page: 1392
  year: 2021
  ident: 25888_CR67
  publication-title: Blood
  doi: 10.1182/blood.2019004617
  contributor:
    fullname: RK Mailer
– volume: 125
  start-page: 3132
  year: 2015
  ident: 25888_CR51
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI77139
  contributor:
    fullname: J Bjorkqvist
– volume: 24
  start-page: 419
  year: 2017
  ident: 25888_CR12
  publication-title: Curr. Opin. Hematol.
  doi: 10.1097/MOH.0000000000000367
  contributor:
    fullname: JK Bickmann
– volume: 92
  start-page: 4198
  year: 1998
  ident: 25888_CR42
  publication-title: Blood
  doi: 10.1182/blood.V92.11.4198
  contributor:
    fullname: F Citarella
– volume: 15
  year: 2020
  ident: 25888_CR53
  publication-title: Orphanet J. Rare Dis.
  doi: 10.1186/s13023-020-01564-9
  contributor:
    fullname: R López-Gálvez
– volume: 32
  start-page: 433
  year: 2018
  ident: 25888_CR10
  publication-title: Blood Rev.
  doi: 10.1016/j.blre.2018.04.001
  contributor:
    fullname: BF Tillman
– volume: 19
  start-page: 371
  year: 1989
  ident: 25888_CR15
  publication-title: Ric. Clin. Lab
  doi: 10.1007/BF02871828
  contributor:
    fullname: AM van den Besselaar
– volume: 129
  start-page: 1707
  year: 2017
  ident: 25888_CR17
  publication-title: Blood
  doi: 10.1182/blood-2016-08-734988
  contributor:
    fullname: JJ Verhoef
– volume: 125
  start-page: 710
  year: 2015
  ident: 25888_CR32
  publication-title: Blood
  doi: 10.1182/blood-2014-01-550285
  contributor:
    fullname: EX Stavrou
– volume: 51
  start-page: e7813
  year: 2018
  ident: 25888_CR52
  publication-title: Braz. J. Med. Biol. Res.
  doi: 10.1590/1414-431x20187813
  contributor:
    fullname: N Fragnan
– volume: 133
  start-page: 1152
  year: 2019
  ident: 25888_CR27
  publication-title: Blood
  doi: 10.1182/blood-2018-06-860270
  contributor:
    fullname: I Ivanov
– volume: 1864
  start-page: 2118
  year: 2017
  ident: 25888_CR20
  publication-title: Biochim Biophys. Acta
  doi: 10.1016/j.bbamcr.2017.07.009
  contributor:
    fullname: H Weidmann
– volume: 86
  start-page: 4134
  year: 1995
  ident: 25888_CR45
  publication-title: Blood
  doi: 10.1182/blood.V86.11.4134.bloodjournal86114134
  contributor:
    fullname: DM Ravon
– volume: 129
  start-page: 1527
  year: 2017
  ident: 25888_CR38
  publication-title: Blood
  doi: 10.1182/blood-2016-10-744110
  contributor:
    fullname: I Ivanov
– volume: 36
  start-page: 148
  year: 2006
  ident: 25888_CR3
  publication-title: Blood Cells Mol. Dis.
  doi: 10.1016/j.bcmd.2005.12.014
  contributor:
    fullname: T Renne
– volume: 37
  start-page: 13
  year: 2017
  ident: 25888_CR9
  publication-title: Arterioscl Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.116.308595
  contributor:
    fullname: KF Nickel
– volume: 295
  start-page: 363
  year: 2020
  ident: 25888_CR46
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA119.009788
  contributor:
    fullname: ZLM Hofman
– volume: 59
  start-page: 1167
  year: 1977
  ident: 25888_CR22
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI108741
  contributor:
    fullname: SD Revak
– volume: 39
  start-page: 37
  year: 2017
  ident: 25888_CR58
  publication-title: Int J. Lab Hemat.
  doi: 10.1111/ijlh.12658
  contributor:
    fullname: DM Adcock
– volume: 43
  start-page: 814
  year: 2017
  ident: 25888_CR2
  publication-title: Sem. Thromb. Hemost.
  doi: 10.1055/s-0036-1598003
  contributor:
    fullname: C Naudin
– volume: 140
  start-page: 118
  year: 2016
  ident: 25888_CR31
  publication-title: Thromb. Res.
  doi: 10.1016/j.thromres.2016.02.020
  contributor:
    fullname: Y Kokoye
– volume: 264
  start-page: 11497
  year: 1989
  ident: 25888_CR41
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)60491-0
  contributor:
    fullname: BJ Clarke
– volume: 141
  start-page: 31
  year: 2011
  ident: 25888_CR54
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2011.07.002
  contributor:
    fullname: K Bork
– volume: 84
  start-page: 1057
  year: 2000
  ident: 25888_CR43
  publication-title: Thromb. Haemost.
  doi: 10.1055/s-0037-1614171
  contributor:
    fullname: F Citarella
– volume: 14
  start-page: 427
  year: 2016
  ident: 25888_CR8
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/jth.13235
  contributor:
    fullname: AT Long
– volume: 114
  start-page: 276
  year: 2000
  ident: 25888_CR14
  publication-title: Am. J. Clin. Pathol.
  doi: 10.1309/4WK2-99F2-VEMB-15YJ
  contributor:
    fullname: ML Brigden
– volume: 118
  start-page: 1340
  year: 2016
  ident: 25888_CR1
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.115.306841
  contributor:
    fullname: AM Wendelboe
– volume: 137
  start-page: 904
  year: 2012
  ident: 25888_CR13
  publication-title: Am. J. Clin. Pathol.
  doi: 10.1309/AJCP3J1ZKYBFQXJM
  contributor:
    fullname: GA Fritsma
– volume: 271
  start-page: 13061
  year: 1996
  ident: 25888_CR61
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.22.13061
  contributor:
    fullname: H Herwald
– volume: 271
  start-page: 13040
  year: 1996
  ident: 25888_CR62
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.22.13040
  contributor:
    fullname: H Herwald
SSID ssj0000391844
Score 2.5245483
Snippet Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated...
Abstract Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the...
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated...
Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify...
SourceID doaj
swepub
pubmedcentral
cristin
proquest
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Publisher
StartPage 5596
SubjectTerms 13/56
13/95
14/1
631/92/612/1221
64/60
692/53/2421
692/699/75/593/567
82/80
Antibodies
Blood clots
Blood coagulation
Clinical medical disciplines: 750
Clotting
Coagulation
Coagulation factor XII
Coagulation factors
Diagnostic systems
Epidermal growth factor
Hematologi: 775
Hematology: 775
Humanities and Social Sciences
Kallikrein
Klinisk medisinske fag: 750
Medical disciplines: 700
Medicin och hälsovetenskap
Medicine
Medisinske Fag: 700
Molecular weight
multidisciplinary
Mutants
Peptides
Plasma
Plasma kallikrein
Plasmin
Reagents
Residues
Science
Science (multidisciplinary)
Standardization
Thrombin
Thromboplastin
Thrombosis
VDP
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELVQJSQuCAqogbYyEjeImvgr9rEgqhYJTlTamxUnY6iQsqjZHvj3zNjepemBXnrYQxJL3njGnnmZmTeMvWuDBRtUrJ3TolaAcMcOIGropXDB9lY4qnf--s2cX6ovK7261eqLcsIyPXBeuBM0KUpEJwJZomFU1khoxoBqqBppIZNtN-4WmEpnsHQIXVSpksGBJ7NKZwJlJAiNsK8mlqchbaRpYZMSdf_C37ybLbkLmd6hF00m6ewZe1p8SX6a3-E5ewTTPnucu0v-ecFCLsKN5ascX0eO3h7PHXb46uKCU546XnEqbsifZjkFkzmkgqqZz5TdTuchjux_lEZffMzZecTv_JJdnn3-_um8Li0V6kG7dlOHNiiERMrYMGj0XSD2Tpp26LWOTjWgrZBaAqKqAOhZgemMCQbtfBAIW2MjX7G9aT3BAeN2DKPUJhrlQDXjEIIKMkKvTDN0OsqKHZTl9RNqM5Ejy84LiYipYu-36-1_Z1INn4Lh0vosJ49y8klOvqvYRxLJbiQRYqcbqCa-qIm_T00qdrgVqC-7dMYJOt0iIlU4x9vdY9xfFDTpJ1jf5DFW4lHsKtYtFGHxh5ZPpqufianbUhTa6op92KrMv8n_98Iiq9VyBjSovtz_dUU_PwMit86gkyz064dYpTfsiaAdQlE3ccj2Ntc3cIRO1yYcp_31F0ByJ0M
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: AUTh Library subscriptions: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR3LbtQwcARbgXpBUEANFGQkbhA161fsE6KoVYvUCiEq7c2KE6etkLKl2R7698zY3q3SQw85JLbixPPwvAfg89ybYLzsS2sVL2VAdce0gZehEdx60xhuKd_59Ewfn8ufC7XIBrcxh1WueWJk1N2yJRv5PicHAWoPsv52_a-krlHkXc0tNJ7CFkdNgc9g6-Dw7NfvjZWF6p8bKXO2TCXM_igjb6DIBK5Q_Sup2lMbCWqYnE2xhP9E7nwYNblxnT4oMxqPpqOX8CLLlOx7QoJX8CQMO_AsdZm824Hnp9l__hp8ysvts6GOLXuGAiBLTXfY4uSEUeg63jHKd0jWWkY7wELMsRrZSAHvxCJxZnORe3-xLgXsUcnnN3B-dPjnx3GZuyyUrbLzVennXqKWJLXxrUJxJvSNFXreNkr1VlZBGS6UCKho-YDCVtC11l7j0e85arJ9Jd7CbFgOYReY6XwnlO61tEFWXeu99KIPjdRVW6teFLCbd9oNiOBUL1nUjgtUogr4st56d53qbLjoHxfGJZA5BJmLIHN1AQcEnc1MqpEdHyxvLlwmOXyvkby33JMM03bSaBGqziMDk_jWgEvurWHrMuGO7h7NCvi0GUaSIz9KM4TlbZpjBHJnW0A9wYnJB01HhqvLWLzbkGPaqAK-rrHnfvHHfpgnDJuugGesy8__XtHlxoDKXK1Rbubq3eM_-B62OZEBudj4HsxWN7fhA0pYK_8xk9F_RZIkvA
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKERIX1PJQA6UyEjcIJH7FPlQIEFWLBCdW2psVJ3apirKw2Ur03zNjO4tSVUgc9pDEm0k8M_Z8mRchL2unvXYilMZIVgoPcEd3npW-5cw43WpmMN_5y1d1uhCfl3K5Q6Z2R3kCx1uhHfaTWqx_vPn96_odKPxxShnXb0cR1R2DDZgERFc2d8hdhoW5MJQvm_txZeYGAI3IuTO3_xXs4C6q1zDbqWJB_5kVejOGcutIvVF0NG5UJ3vkQbYw6fskEvtkxw8Pyb3Uc_L6EXEpNTfkb3V0FSjYgDT13aHLszOK0etwRDHlIX2wpehipj6mWY10xJh3XCVhZHue23_RPsXsYdXnx2Rx8unbx9MyN1ooO2nqTelqJwAoCaVdJ8Gi8aE1XNVdK2UwovJSMy65B6zlPNhbXjVKOQW7v2MAZkPFn5DdYTX4A0J173ouVVDCeFH1nXPC8eBboaqukYEX5CBPrx1AxrFkMm8s44CjCvJqmm_7M5XasNFFzrVNfLLAJxv5ZJuCfECWbEdimex4YrU-t1nr4L5asGCYQzOm64VW3Fe9gzVMwF09kDycGGon0QMCjawBpwqg8WJ7GbQOXSnt4FdXaYzmsECbgjQzQZg90PzKcPE91u_W6JvWsiCvJ5H5S_xfL8ySWM0pwDZr8_nLC_zZ0QOeaxSYzkw-_T8az8h9hrqAXjd2SHY36yv_HIyujTuKmvQHiK8nrw
  priority: 102
  providerName: Scholars Portal
– databaseName: SpringerOpen
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR1Nb9UwLIIhJC6I8aEVNhQkblDR5qvJEZ6YtklwYtK7RU3rwITUN9G3A_8eO8l7qBOaxKGHNmnd1nZsx1-MvW2DBRtUrJ3TolaA5o4dQNTQS-GC7a1wlO_85as5u1QXa70uZXIoF2bhv5f2w6wSK1MggdBordXdffaAZDC1aViZ1X4_hSqdW6VKXsy_b0Udd0isMy2kUCrWv9Awb8dH7p2ktwqKJiF0-oQ9Ltoj_5jRfcjuwfSUPcz9JH8_YyGn3cayD8c3kaN-x3NPHb4-P-cUmY5nnNIZ8mYsJ_cxh5RCNfOZ4tlpBcSZ_ffS2ouPOR6PKjo_Z5enn7-tzurSRKEetGu3dWiDQiNIGRsGjdoKxN5J0w691tGpBrQVUktAOyoA6lJgOmOCQckeBBqqsZEv2MG0meCIcTuGUWoTjXKgmnEIQQUZoVemGTodZcWOyu_1E9IvlUOWnRcSbaSKvdv9b3-dy2j45P6W1mc8ecSTT3jyXcU-EUr2M6kEdrqAlOELR-FzrRLRiUAqyjAqayQ0Y8D1SeFTAUEe7xDqC1_OCKDTLdqgCmG82Q8jR5GbpJ9gc5PnWImLr6tYtyCExQstR6arH6k2tyW_s9UVe78jmb_A7_pgkclqCQFFqC_Xf17R4WdAW60zqBYL_fL_YLxijwTxAnnUxDE72P66gRNUqLbhdeKkP7gwGSg
  priority: 102
  providerName: Springer Nature
Title Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
URI https://link.springer.com/article/10.1038/s41467-021-25888-7
https://www.proquest.com/docview/2575160147
https://search.proquest.com/docview/2575838879
http://hdl.handle.net/10037/23606
https://pubmed.ncbi.nlm.nih.gov/PMC8458485
http://kipublications.ki.se/Default.aspx?queryparsed=id:147695125
https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1NT9sw1AImpF2mfYoMVnnSblto4q_Yx1LRQaUitA2pNytObKg2UkTKgX-_Z8fpFg477NBUdaw8N-_D7_l9IfQpN9JKw1yqFCcps2DuyMqS1JaUKCNLSZTPd15ciLMrNl_y5Q7ifS5MCNqvzOq4-XV73KxuQmzl3W017uPExpeLqfTOPcnHu2gXCPQvEz2IX6rAamExQSajctyyIA58MALhYPGlvvMeZZyTzKdQ71eBnZrBzhQK-A-0zqcxk1vH6ZMio2Fjmr1EL6JGiSfdyl-hHdu8Rvtdj8nHN8h0qbguns3htcOg8-Guzw5enp9jH60Ov7BPcegOaLF3KWMb0qpa3PoYdy8VYWZ5Hdt94bqL0fNVnt-iq9npj-lZGhsrpBVX-SY1uWFgGDEhTcVBg7GuVFTkVcm5UyyzXBLKqQXbyljQr6wohDACdntDwHh1GX2H9pp1Yw8QlrWpKRdOMGVZVlfGMEOdLZnIqoI7mqCD-Hp1AzTtSyTTQhMKdlOCPvfvW991pTV0cIlTqTuUaUCZDijTRYJOPEq2M31Z7DCwvr_WkTjguZIRp4jxaktVMymozWoDMovBUy2APOoRqiOvtgCg4DnYpQxgfNzeBi7zrpOyseuHbo6kIJBVgooBIQwWNLwD5BvqdUdyTdCXnmT-AP_XHyYdWQ0hwLaq4_jPlf_o1oL9VghQlQl__9-rO0TPiecQ73AjR2hvc_9gP4C-tTEj4LJlAVc5-zpCzyaT-fc5fJ-cXlx-g9GpmI7CSQZcF0yOAjf-BmrLMNY
link.rule.ids 230,315,730,783,787,867,888,2109,2228,12070,12779,21402,24332,27938,27939,31733,31734,33387,33388,33758,33759,41134,42203,43324,43614,43819,51590,53806,53808,74081,74371,74638
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagiMcFQQE1UMBI3CBq1q_YJwSIahe6PbXS3qw4sUuFlLTN9tB_z4zt3So99LCHTaw4jmfG8_yGkM8zp712IpTGSFYKD-aObj0rfcOZcbrRzGC98_JYzU_F75VcZYfbmNMqNzIxCupuaNFHfsAwQADWg6i_XVyW2DUKo6u5hcZD8ghxuBA7v17VWx8Lop9rIXKtTMX1wSiiZMC8BCbB-CsR66mN7NRPTqYI4D_ROu_mTG4Dp3dARuPBdPiCPM8aJf2eSOAleeD7XfI49Zi82SVPljl6_oq4VJUbspuODoGC-kdTyx26WiwoJq7DP4rVDslXS3H91McKq5GOmO6OAhJGNme58xftUroeAj6_JqeHv05-zsvcY6FspZmtSzdzAmwkobRrJSgzPjSGq1nbSBmMqLzUjEvuwcxyHlQtr2qlnIKD3zGwY0PF35Cdfuj9HqG6cx2XKihhvKi61jnhePCNUFVby8ALspe_tO2BvBEtmdeWcTChCvJl8-ntRULZsDE6zrVNW2Zhy2zcMlsX5AfuznYkImTHC8PVmc0MB8_VggXDHGowbSe04r7qHIgvAU_1MOX-Zm9tZtvR3hJZQT5tbwPDYRSl6f1wncZoDrLZFKSe0MTkhaZ3-vO_EbpbY1hay4J83VDP7eT3LZglCpvOACeszdf_nePPjh5MuVqB1szk2_sX-JE8nZ8sj-zR4vjPO_KMIUtgsI3tk5311bV_D7rW2n2IDPUfSYgmRw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVlRcEBRQAwWMxA2izfoV54QodNUFuqoQlfZmxYndVkhJabYH_j0ziXer9NDDHjax4sTz8Ixn5huADzNnvHEypEWheCo9ujum8jz1peCFM6XhBdU7nyz18Zn8vlKrmP_UxbTKjU7sFXXdVnRGPuUUIEDvQebTENMiTr_NP1_9TamDFEVaYzuNh7CTS-SqCewcHi1Pf21PXAgL3UgZK2cyYaad7PUEZSlwha5gSshPVS9czWif6uH8Rzbo3QzKbRj1DuRov03Nn8KTaF-yLwNDPIMHvtmDR0PHyX97sHsSY-nPwQ01uiEe2rE2MDQG2dCAh60WC0Zp7PiPUe3DcHLLaAWY7-utOtZR8jupSxxZnsc-YKwekvcI_vkFnM2Pfn89TmPHhbRSxWydupmT6DFJbVyl0LTxoSyEnlWlUqGQmVeGCyU8Ol3Oo-Hlda6102gGOI5ebcjES5g0beP3gZna1ULpoGXhZVZXzkkngi-lzqpcBZHAflxp2yCzE3ayyC0X6FAl8HGz9PZqwNywfaxcGDuQzCLJbE8ymydwSNTZjiS87P5Ce31uo_jhc43koeCO7JmqlkYLn9UOlZnEp3qc8mBDWxuFuLO3LJfA--1tFD-KqZSNb2-GMUagpi4SyEc8MXqh8Z3m8qIH8jYUpDYqgU8b7rmd_L4P5gOHjWfA_dbG638u6Wc7j45drtGG5urV_R_4DnZRmuzPxfLHa3jMSSIo8sYPYLK-vvFv0PBau7dRov4DVikr6g
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+the+factor+XII+contact+activation+site+enables+sensitive+coagulation+diagnostics&rft.jtitle=Nature+communications&rft.au=Heestermans%2C+Marco&rft.au=Naudin%2C+Cl%C3%A9ment&rft.au=Mailer%2C+Reiner+K.&rft.au=Konrath%2C+Sandra&rft.date=2021-09-22&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=12&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-021-25888-7&rft.externalDocID=10_1038_s41467_021_25888_7
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon