Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture

• Published in: American journal of human genetics Vol. 97; no. 6; pp. 816 - 836
• Main Authors: Stuart, Philip E., Nair, Rajan P., Tsoi, Lam C., Tejasvi, Trilokraj, Das, Sayantan, Kang, Hyun Min, Ellinghaus, Eva, Chandran, Vinod, Callis-Duffin, Kristina, Ike, Robert, Li, Yanming, Wen, Xiaoquan, Enerbäck, Charlotta, Gudjonsson, Johann E., Kõks, Sulev, Kingo, Külli, Esko, Tõnu, Mrowietz, Ulrich, Reis, Andre, Wichmann, H. Erich, Gieger, Christian, Hoffmann, Per, Nöthen, Markus M., Winkelmann, Juliane, Kunz, Manfred, Moreta, Elvia G., Mease, Philip J., Ritchlin, Christopher T., Bowcock, Anne M., Krueger, Gerald G., Lim, Henry W., Weidinger, Stephan, Weichenthal, Michael, Voorhees, John J., Rahman, Proton, Gregersen, Peter K., Franke, Andre, Gladman, Dafna D., Abecasis, Gonçalo R., Elder, James T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.12.2015; Cell Press; Elsevier
• Subjects: Adolescent; Adult; Arthritis, Psoriatic - genetics; Arthritis, Psoriatic - pathology; Bayes Theorem; Case-Control Studies; Cornified Envelope Proline-Rich Proteins - genetics; DNA-Binding Proteins - genetics; Female; Genetic Loci; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study; Genotype & phenotype; HLA-C Antigens - genetics; Humans; Intracellular Signaling Peptides and Proteins - genetics; joint diseases; Linkage Disequilibrium; Male; Meta-analysis; Nuclear Proteins - genetics; Polymorphism, Single Nucleotide; Psoriasis; Psoriasis - genetics; Psoriasis - pathology; psoriatic arthritis; Receptors, Interleukin - genetics; Risk factors; skin diseases; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics; psoriatic arthritis; psoriasis; skin diseases; joint diseases; genome-wide association study

Psoriasis vulgaris (PsV) is a common inflammatory and hyperproliferative skin disease. Up to 30% of people with PsV eventually develop psoriatic arthritis (PsA), an inflammatory musculoskeletal condition. To discern differences in genetic risk factors for PsA and cutaneous-only psoriasis (PsC), we c...