Cardiac work is related to creatine kinase energy supply in human heart failure: a cardiovascular magnetic resonance spectroscopy study

• Published in: Journal of cardiovascular magnetic resonance Vol. 20; no. 1; pp. 81 - 11
• Main Authors: Gabr, Refaat E., El-Sharkawy, AbdEl-Monem M., Schär, Michael, Panjrath, Gurusher S., Gerstenblith, Gary, Weiss, Robert G., Bottomley, Paul A.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.12.2018; BioMed Central; Elsevier
• Subjects: Adenosine triphosphate; Adenosine Triphosphate - metabolism; Adult; Age; Biomarkers - metabolism; Cardiac metabolism; Cardiac work; Cardiomyopathy; Care and treatment; Case-Control Studies; Chemical energy; Collaboration; Creatine; Creatine kinase; Creatine Kinase - metabolism; Deprivation; Diabetes; Diagnosis; Efficiency; Energy; Energy Metabolism; Energy requirements; Female; Flux; Heart; Heart diseases; Heart failure; Heart Failure - diagnosis; Heart Failure - enzymology; Heart Failure - physiopathology; Humans; Hypertension; Hypotheses; Magnetic resonance; Magnetic resonance imaging; Magnetic Resonance Imaging, Cine; Magnetic resonance spectroscopy; Magnetic Resonance Spectroscopy - methods; Male; Mechanical efficiency; Mechanical properties; Medical imaging; Metabolism; Metabolites; Middle Aged; Mutation; Myocardial Contraction; Myocardium - enzymology; NMR; Nuclear magnetic resonance; Organic chemistry; Patients; Phosphorus; Predictive Value of Tests; Spectrum analysis; Stroke Volume; Translational studies; Ventricular Function, Left; Heart failure; Translational studies; Cardiac metabolism; Magnetic resonance; Cardiac work

It has been hypothesized that the supply of chemical energy may be insufficient to fuel normal mechanical pump function in heart failure (HF). The creatine kinase (CK) reaction serves as the heart's primary energy reserve, and the supply of adenosine triphosphate (ATP flux) it provides is reduc...