Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes - Dubuquoy, Céline; Robichon, Céline; Lasnier, Françoise; Langlois, Clotilde; Dugail, Isabelle; Foufelle, Fabienne; Girard, Jean; Burnol, Anne-Françoise; Postic, Catherine; Moldes, Marthe (Journal of hepatology, 2011)
Keywords: Adiponutrin; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; Binding Sites - genetics; Biological and medical sciences; ChREBP; Fatty Liver - etiology; Fatty Liver - genetics; Fatty Liver - metabolism; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation - drug effects; Glucose - pharmacology; HEK293 Cells; Hep G2 Cells; Hepatic steatosis; Hepatocytes - drug effects; Hepatocytes - metabolism; HepG2; Humans; IHH; In Vitro Techniques; Insulin - pharmacology; Life Sciences; Lipase - genetics; Lipogenesis; Liver; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Membrane Proteins - genetics; Mice; Mice, Inbred C57BL; NAFLD; Non-alcoholic Fatty Liver Disease; Nuclear Proteins - metabolism; Nutritional Status; Other diseases. Semiology; Phospholipases A2, Calcium-Independent - genetics; PNPLA3; Promoter Regions, Genetic; SREBP1c; Sterol Regulatory Element Binding Protein 1 - metabolism; Transcription Factors - metabolism; FFA; NAFLD; ATGL; Liver; SRE; IHH; GFP; HEK293; SNP; HepG2; SREBP1c; SCD1; ChoRE; Lipogenesis; Adiponutrin; Hepatic steatosis; NASH; ChREBP; TG; PNPLA3; FAS; SREBP1c-DN; ChIP-chip; pfu; ADPN; L-PK; liver-pyruvate kinase; non-alcoholic fatty liver disease; single nucleotide polymorphism; sterol regulatory element binding protein1c; free fatty acids; carbohydrate response element; sterol response element; adiponutrin; adipose triglyceride lipase; patatin-like phospholipase domain containing protein; human embryonic kidney cells; carbohydrate-response element-binding protein; sterol regulatory element binding protein-1c-dominant negative; plaque-forming units; triglycerides; green fluorescent protein; immortalized human hepatocytes; stearoyl-CoA desaturase 1; fatty acid synthase; chromatin immunoprecipitation combined with genome tiling arrays; human hepatocellular carcinoma cell line; non-alcoholic steatohepatitis; Human; Rodentia; Hepatic disease; Gene expression; Vertebrata; Mammalia; Fatty liver; Hepatocyte