Whole-genome sequencing to explore nosocomial transmission and virulence in neonatal methicillin-susceptible Staphylococcus aureus bacteremia

• Published in: Antimicrobial resistance & infection control Vol. 9; no. 1; pp. 39 - 7
• Main Authors: Slingerland, Bibi C G C, Vos, Margreet C, Bras, Willeke, Kornelisse, René F, De Coninck, Dieter, van Belkum, Alex, Reiss, Irwin K M, Goessens, Wil H F, Klaassen, Corné H W, Verkaik, Nelianne J
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.02.2020; BioMed Central; BMC
• Subjects: Algorithms; Analysis; Bacteremia; Bacteremia - microbiology; Bacteremia - transmission; Bacterial Toxins - genetics; Bacterial Typing Techniques; Birth weight; Blood tests; Cross Infection - microbiology; Cross Infection - transmission; Disease control; DNA sequencing; Drug resistance; Enterotoxins - genetics; Female; Genes; Genetic research; Genome, Bacterial; Genomes; Genomics; Health aspects; Humans; Infant, Newborn; Intensive care; Intensive Care Units, Neonatal; Male; Medical research; Methicillin; Morbidity; Mortality; Multilocus Sequence Typing; Neonatal intensive care; Neonatal intensive care unit; Neonates; Netherlands; Netherlands - epidemiology; Newborn babies; Newborn infants; Nosocomial infection; Pathogens; Penicillin; Retrospective Studies; Septic shock; Shock; Staphylococcal Infections - transmission; Staphylococcus aureus; Staphylococcus aureus - genetics; Staphylococcus aureus - isolation & purification; Staphylococcus aureus - pathogenicity; Staphylococcus infections; Superantigens - genetics; Time; Toxic shock syndrome; Toxins; Transmission; Virulence; Virulence (Microbiology); Whole Genome Sequencing - methods; Whole-genome sequencing; Netherlands; Germany; Neonatal intensive care unit; Whole-genome sequencing; Bacteremia; Staphylococcus aureus; Transmission

Neonatal Staphylococcus aureus (S. aureus) bacteremia is an important cause of morbidity and mortality. In this study, we examined whether methicillin-susceptible S. aureus (MSSA) transmission and genetic makeup contribute to the occurrence of neonatal S. aureus bacteremia. A retrospective, single-c...