Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma

• Published in: BMC medicine Vol. 17; no. 1; pp. 106 - 13
• Main Authors: Tian, Meng-Xin, Liu, Wei-Ren, Wang, Han, Zhou, Yu-Fu, Jin, Lei, Jiang, Xi-Fei, Tao, Chen-Yang, Tang, Zheng, Zhou, Pei-Yun, Fang, Yuan, Qu, Wei-Feng, Ding, Zhen-Bin, Peng, Yuan-Fei, Dai, Zhi, Qiu, Shuang-Jian, Zhou, Jian, Lau, Wan Yee, Fan, Jia, Shi, Ying-Hong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.06.2019; BioMed Central; BMC
• Subjects: Adult; Aged; B cells; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Cancer; Carcinoma; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Cohort Studies; Colorectal cancer; Cytokines; Cytotoxicity; Female; Gene amplification; Genomes; Hepatocellular carcinoma; Hepatology; Homogeneity; Humans; Immune signature; Immunohistochemistry; Immunophenotyping - methods; Liver cancer; Liver Neoplasms - diagnosis; Liver Neoplasms - metabolism; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Lymphocytes; Lymphocytes - pathology; Lymphocytes, Tumor-Infiltrating - metabolism; Lymphocytes, Tumor-Infiltrating - pathology; Male; Medical prognosis; Medical research; Metastasis; Middle Aged; Multivariate analysis; Neoplasm Staging; Novels; Patient outcomes; Patients; Performance assessment; Prognosis; Regression analysis; Regression models; Subgroups; Surgery; Survival; Survival Analysis; Survival prediction; Tissue Array Analysis; Training; Transcriptome; Tumors; Survival prediction; Hepatocellular carcinoma; Prognosis; Immune signature

Intratumoral immune infiltrates have manifested a robust prognostic signature in patients with hepatocellular carcinoma (HCC). We hypothesized that a novel tissue-related immune signature (TRIS) could improve the prediction of postoperative survival for patients diagnosed with early/intermediate HCC...