Tissue Transglutaminase Is an Essential Participant in the Epidermal Growth Factor-stimulated Signaling Pathway Leading to Cancer Cell Migration and Invasion

• Published in: The Journal of biological chemistry Vol. 284; no. 27; pp. 17914 - 17925
• Main Authors: Antonyak, Marc A., Li, Bo, Regan, Andrew D., Feng, Qiyu, Dusaban, Stephanie S., Cerione, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.07.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Membrane - enzymology; Cell Movement - physiology; Cell Survival - physiology; Enzyme Activation - physiology; Epidermal Growth Factor - metabolism; Female; Genes, ras - physiology; GTP-Binding Proteins; Guanosine Triphosphate - metabolism; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases - metabolism; Mechanisms of Signal Transduction; Neoplasm Invasiveness; RNA, Small Interfering; Signal Transduction - physiology; Transglutaminases - genetics; Transglutaminases - metabolism

Epidermal growth factor (EGF) exerts pleiotropic effects during oncogenesis, including the stimulation of cell migration and invasiveness. Although a number of traditional signaling proteins (e.g. Ras and Rho GTPases) have been implicated in EGF-stimulated cancer cell migration, less is known about...