Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis

• Published in: Journal of hematology and oncology Vol. 10; no. 1; pp. 11 - 12
• Main Authors: Chang, Yu-Chan, Chi, Li-Hsing, Chang, Wei-Ming, Su, Chia-Yi, Lin, Yuang-Feng, Chen, Chi-Long, Chen, Ming-Huang, Chang, Peter Mu-Hsin, Wu, Alex T. H., Hsiao, Michael
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.01.2017; BioMed Central; BMC
• Subjects: Cancer cells; Cancer therapies; Carcinoma, Squamous Cell - chemically induced; Carcinoma, Squamous Cell - pathology; Carrier Proteins - metabolism; Carrier Proteins - physiology; Cell growth; Cell Line, Tumor; Cell Movement; Chemotherapy; Cloning; Computer Simulation; DDX58; DEAD Box Protein 58 - drug effects; DEAD Box Protein 58 - metabolism; Development and progression; Gene expression; Gene Expression Profiling; Genomes; Glucose; Glucose - metabolism; Glucose Transporter Type 4 - analysis; Glucose Transporter Type 4 - metabolism; GLUT4; Head and neck cancer; Head and Neck Neoplasms - chemically induced; Head and Neck Neoplasms - pathology; Hematology; HNSCC; Humans; Medical prognosis; Membrane proteins; Metabolism; Metastasis; Neoplasm Metastasis; Oncology; Patients; Physiological aspects; Prognosis; Receptors, Immunologic; Squamous Cell Carcinoma of Head and Neck; Tissue Array Analysis; TRIM24; Taiwan; Palo Alto California; St Louis Missouri; United States > US; TRIM24; Metastasis; GLUT4; DDX58; HNSCC
• ISSN: 1756-8722; 1756-8722
• DOI: 10.1186/s13045-016-0372-0

Head and neck squamous cell carcinoma (HNSCC) represents a unique and major health concern worldwide. Significant increases in glucose uptake and aerobic glycolysis have been observed in HNSCC cells. Glucose transporters (GLUTs) represent a major hub in the glycolysis pathway, with GLUT4 having the...