Cure of recurring Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae septic shock episodes due to complicated soft tissue infection using a ceftazidime and avibactam-based regimen: a case report

• Published in: Journal of medical case reports Vol. 13; no. 1; p. 20
• Main Authors: Parruti, Giustino, Frattari, Antonella, Polilli, Ennio, Savini, Vincenzo, Sciacca, Antonina, Consorte, Augusta, Cibelli, Donatella Concetta, Agostinone, Adriana, Di Masi, Francesco, Pieri, Alessandro, Cacciatore, Pierluigi, Di Iorio, Giancarlo, Fazii, Paolo, Spina, Tullio
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.01.2019; BioMed Central; BMC
• Subjects: Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics; Azabicyclo Compounds - therapeutic use; Back pain; Beta lactamases; Care and treatment; Case Report; Case reports; Ceftazidime; Ceftazidime - therapeutic use; Cephalosporins; Device Removal; Dosage and administration; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug therapy; Enterobacteriaceae; Ethics; Evacuations & rescues; External Fixators - adverse effects; External Fixators - microbiology; Fracture Fixation; Fractures (Injuries); Hospitals; Humans; Infection; Infections; Infectious diseases; Klebsiella; Klebsiella Infections - drug therapy; Klebsiella Infections - microbiology; Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae; Male; Marketing; Medical ethics; Microbial drug resistance; Middle Aged; Mortality; Paralysis; Paraplegia; Patients; Prosthesis-Related Infections - drug therapy; Prosthesis-Related Infections - microbiology; Protease inhibitors; Risk factors; Sepsis; Septic shock; Shock; Shock, Septic - drug therapy; Skin; Soft Tissue Infections - drug therapy; Soft Tissue Infections - microbiology; Suicide; Tigecycline; Treatment; Treatment Outcome; Italy; Sepsis; Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae; Treatment

Infections caused by multidrug-resistant Enterobacteriaceae are hard to treat and life-threatening due to reduced therapeutic options. Systemic infections caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae strains have increased in many European regions, becoming frequent...