Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease

• Published in: Genome Biology Vol. 20; no. 1; p. 2
• Main Authors: Oh, Gabriel, Koncevičius, Karolis, Ebrahimi, Sasha, Carlucci, Matthew, Groot, Daniel Erik, Nair, Akhil, Zhang, Aiping, Kriščiūnas, Algimantas, Oh, Edward S., Labrie, Viviane, Wong, Albert H. C., Gordevičius, Juozas, Jia, Peixin, Susic, Miki, Petronis, Art
• Format: Journal Article
• Language: English
• Published: England BioMed Central 03.01.2019; BMC
• Subjects: Adaptation; Aging; Aging - metabolism; Circadian; Circadian Rhythm; Circadian rhythms; Cytosine; Cytosine - metabolism; Demethylation; Diabetes; Differentiation; DNA methylation; DNA modification; Epigenesis, Genetic; Epigenetics; Gene regulation; genes; human health; Humans; Leukemia, Lymphocytic, Chronic, B-Cell - metabolism; Leukocytes (neutrophilic); Male; Methylation; Middle Aged; neutrophils; Neutrophils - metabolism; Oscillations; risk; Schizophrenia - metabolism; Studies; United States > US; Disease; Leukemia; Aging; Epigenetics; Schizophrenia; DNA modification; Diabetes; Circadian; Differentiation; Methylation

Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. Extending our recent findings of oscillating cytosine modifications (osc-mo...