Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease

Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. Extending our recent findings of oscillating cytosine modifications (osc-mo...

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Published inGenome Biology Vol. 20; no. 1; p. 2
Main Authors Oh, Gabriel, Koncevičius, Karolis, Ebrahimi, Sasha, Carlucci, Matthew, Groot, Daniel Erik, Nair, Akhil, Zhang, Aiping, Kriščiūnas, Algimantas, Oh, Edward S., Labrie, Viviane, Wong, Albert H. C., Gordevičius, Juozas, Jia, Peixin, Susic, Miki, Petronis, Art
Format Journal Article
LanguageEnglish
Published England BioMed Central 03.01.2019
BMC
Subjects
Adaptation
Aging
Aging - metabolism
Circadian
Circadian Rhythm
Circadian rhythms
Cytosine
Cytosine - metabolism
Demethylation
Diabetes
Differentiation
DNA methylation
DNA modification
Epigenesis, Genetic
Epigenetics
Gene regulation
genes
human health
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Leukocytes (neutrophilic)
Male
Methylation
Middle Aged
neutrophils
Neutrophils - metabolism
Oscillations
risk
Schizophrenia - metabolism
Studies
United States > US
Disease
Leukemia
Aging
Epigenetics
Schizophrenia
DNA modification
Diabetes
Circadian
Differentiation
Methylation
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Abstract Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. Extending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human neutrophils. Osc-modCs may play a role in gene regulation, can explain parts of intra- and inter-individual epigenetic variation, and are signatures of aging. Finally, we show that osc-modCs are linked to three complex diseases and provide a new interpretation of cross-sectional epigenome-wide association studies. Our findings suggest that loss of balance between cytosine methylation and demethylation during the circadian cycle can be a potential mechanism for complex disease. Additional experiments, however, are required to investigate the possible involvement of confounding effects, such as hidden cellular heterogeneity. Circadian rhythmicity, one of the key adaptations of life forms on Earth, may contribute to frailty later in life.
AbstractList BACKGROUND: Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. RESULTS: Extending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human neutrophils. Osc-modCs may play a role in gene regulation, can explain parts of intra- and inter-individual epigenetic variation, and are signatures of aging. Finally, we show that osc-modCs are linked to three complex diseases and provide a new interpretation of cross-sectional epigenome-wide association studies. CONCLUSIONS: Our findings suggest that loss of balance between cytosine methylation and demethylation during the circadian cycle can be a potential mechanism for complex disease. Additional experiments, however, are required to investigate the possible involvement of confounding effects, such as hidden cellular heterogeneity. Circadian rhythmicity, one of the key adaptations of life forms on Earth, may contribute to frailty later in life.
Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases.BACKGROUNDMaintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases.Extending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human neutrophils. Osc-modCs may play a role in gene regulation, can explain parts of intra- and inter-individual epigenetic variation, and are signatures of aging. Finally, we show that osc-modCs are linked to three complex diseases and provide a new interpretation of cross-sectional epigenome-wide association studies.RESULTSExtending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human neutrophils. Osc-modCs may play a role in gene regulation, can explain parts of intra- and inter-individual epigenetic variation, and are signatures of aging. Finally, we show that osc-modCs are linked to three complex diseases and provide a new interpretation of cross-sectional epigenome-wide association studies.Our findings suggest that loss of balance between cytosine methylation and demethylation during the circadian cycle can be a potential mechanism for complex disease. Additional experiments, however, are required to investigate the possible involvement of confounding effects, such as hidden cellular heterogeneity. Circadian rhythmicity, one of the key adaptations of life forms on Earth, may contribute to frailty later in life.CONCLUSIONSOur findings suggest that loss of balance between cytosine methylation and demethylation during the circadian cycle can be a potential mechanism for complex disease. Additional experiments, however, are required to investigate the possible involvement of confounding effects, such as hidden cellular heterogeneity. Circadian rhythmicity, one of the key adaptations of life forms on Earth, may contribute to frailty later in life.
BackgroundMaintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases.ResultsExtending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human neutrophils. Osc-modCs may play a role in gene regulation, can explain parts of intra- and inter-individual epigenetic variation, and are signatures of aging. Finally, we show that osc-modCs are linked to three complex diseases and provide a new interpretation of cross-sectional epigenome-wide association studies.ConclusionsOur findings suggest that loss of balance between cytosine methylation and demethylation during the circadian cycle can be a potential mechanism for complex disease. Additional experiments, however, are required to investigate the possible involvement of confounding effects, such as hidden cellular heterogeneity. Circadian rhythmicity, one of the key adaptations of life forms on Earth, may contribute to frailty later in life.
Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. Extending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human neutrophils. Osc-modCs may play a role in gene regulation, can explain parts of intra- and inter-individual epigenetic variation, and are signatures of aging. Finally, we show that osc-modCs are linked to three complex diseases and provide a new interpretation of cross-sectional epigenome-wide association studies. Our findings suggest that loss of balance between cytosine methylation and demethylation during the circadian cycle can be a potential mechanism for complex disease. Additional experiments, however, are required to investigate the possible involvement of confounding effects, such as hidden cellular heterogeneity. Circadian rhythmicity, one of the key adaptations of life forms on Earth, may contribute to frailty later in life.
Abstract Background Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. Results Extending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human neutrophils. Osc-modCs may play a role in gene regulation, can explain parts of intra- and inter-individual epigenetic variation, and are signatures of aging. Finally, we show that osc-modCs are linked to three complex diseases and provide a new interpretation of cross-sectional epigenome-wide association studies. Conclusions Our findings suggest that loss of balance between cytosine methylation and demethylation during the circadian cycle can be a potential mechanism for complex disease. Additional experiments, however, are required to investigate the possible involvement of confounding effects, such as hidden cellular heterogeneity. Circadian rhythmicity, one of the key adaptations of life forms on Earth, may contribute to frailty later in life.
ArticleNumber 2
Author Petronis, Art
Groot, Daniel Erik
Zhang, Aiping
Ebrahimi, Sasha
Labrie, Viviane
Koncevičius, Karolis
Carlucci, Matthew
Gordevičius, Juozas
Susic, Miki
Oh, Edward S.
Oh, Gabriel
Kriščiūnas, Algimantas
Jia, Peixin
Wong, Albert H. C.
Nair, Akhil
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Issue 1
Keywords Disease
Leukemia
Aging
Epigenetics
Schizophrenia
DNA modification
Diabetes
Circadian
Differentiation
Methylation
Language English
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Snippet Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may...
BackgroundMaintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm...
BACKGROUND: Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm...
Abstract Background Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of...
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StartPage 2
SubjectTerms Adaptation
Aging
Aging - metabolism
Circadian
Circadian Rhythm
Circadian rhythms
Cytosine
Cytosine - metabolism
Demethylation
Diabetes
Differentiation
DNA methylation
DNA modification
Epigenesis, Genetic
Epigenetics
Gene regulation
genes
human health
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Leukocytes (neutrophilic)
Male
Methylation
Middle Aged
neutrophils
Neutrophils - metabolism
Oscillations
risk
Schizophrenia - metabolism
Studies
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Title Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
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