The putative tumour suppressor miR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1

• Published in: Journal of experimental & clinical cancer research Vol. 37; no. 1; pp. 219 - 15
• Main Authors: Li, Sen-Mao, Wu, Huan-Lei, Yu, Xiao, Tang, Kun, Wang, Shao-Gang, Ye, Zhang-Qun, Hu, Jia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.09.2018; BioMed Central; BMC
• Subjects: Apoptosis; Cell growth; Diagnosis; Gene expression; Kinases; MicroRNA; Patient outcomes; Proliferation; Prostate cancer; Target gene; United States; microRNA; Proliferation; Prostate cancer; Target gene

Previous studies report that miR-1-3p, a member of the microRNA-1 family (miR-1), and functions as a tumor suppressor in several different cancers. However, little is known regarding the biological role and intrinsic regulatory mechanisms of miR-1-3p in prostate cancer (PCa). In this study, the expr...