The BabySeq project: implementing genomic sequencing in newborns

• Published in: BMC pediatrics Vol. 18; no. 1; p. 225
• Main Authors: Holm, Ingrid A, Agrawal, Pankaj B, Ceyhan-Birsoy, Ozge, Christensen, Kurt D, Fayer, Shawn, Frankel, Leslie A, Genetti, Casie A, Krier, Joel B, LaMay, Rebecca C, Levy, Harvey L, McGuire, Amy L, Parad, Richard B, Park, Peter J, Pereira, Stacey, Rehm, Heidi L, Schwartz, Talia S, Waisbren, Susan E, Yu, Timothy W, Green, Robert C, Beggs, Alan H
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.07.2018; BioMed Central; BMC
• Subjects: Analysis; Clinical trials; DNA sequencing; Early intervention; Ethical, legal, social implications; Ethics; Families & family life; Family - psychology; Family medical history; FDA approval; Genetic aspects; Genetic Counseling; Genetic Predisposition to Disease - psychology; Genetics; Genomes; Genomics; Health aspects; Health care; Health Care Costs; Humans; Infant, Newborn; Medical screening; Medicine; Methods; Neonatal Screening - economics; Neonatal Screening - methods; Neonatal Screening - psychology; Newborn babies; Newborn infants; Newborn screening; Newborn sequencing; Randomized trial; Risk Assessment; Study Protocol; Whole Exome Sequencing; United States; Newborn screening; Newborn sequencing; Randomized trial; Whole exome sequencing; Ethical, legal, social implications; Methods

The greatest opportunity for lifelong impact of genomic sequencing is during the newborn period. The "BabySeq Project" is a randomized trial that explores the medical, behavioral, and economic impacts of integrating genomic sequencing into the care of healthy and sick newborns. Families of...