Transgenic mouse model for the study of enterovirus 71 neuropathogenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 36; pp. 14753 - 14758
• Main Authors: Fujii, Ken, Nagata, Noriyo, Sato, Yuko, Ong, Kien Chai, Wong, Kum Thong, Yamayoshi, Seiya, Shimanuki, Midori, Shitara, Hiroshi, Taya, Choji, Koike, Satoshi
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 03.09.2013; National Acad Sciences
• Subjects: Animal models; Animals; Biological Sciences; Blotting, Western; Brain - metabolism; Brain - pathology; Brain - virology; Cell Line, Tumor; Central Nervous System Diseases - genetics; Central Nervous System Diseases - metabolism; Central Nervous System Diseases - virology; Chlorocebus aethiops; Disease models; Disease Models, Animal; Enterovirus; Enterovirus A, Human - physiology; Enterovirus Infections - genetics; Enterovirus Infections - metabolism; Enterovirus Infections - virology; Epidemics; Hand foot and mouth disease; Host-Pathogen Interactions; Humans; Immunohistochemistry; Infections; Lysosomal Membrane Proteins - genetics; Lysosomal Membrane Proteins - metabolism; Medical ethics; Mice; Mice, Transgenic; Nervous system diseases; Neurology; Neurons; Pathogenesis; Pathology; Receptors; Receptors, Scavenger - genetics; Receptors, Scavenger - metabolism; Rodents; Spinal Cord - metabolism; Spinal Cord - pathology; Spinal Cord - virology; Time Factors; Vero Cells; Virology; Viruses; Asia-Pacific region; neurotropism; viral receptor; picornavirus

Enterovirus 71 (EV71) typically causes mild hand-foot-and-mouth disease in children, but it can also cause severe neurological disease. Recently, epidemic outbreaks of EV71 with significant mortality have been reported in the Asia-Pacific region, and EV71 infection has become a serious public health...