Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing

• Published in: Genome medicine Vol. 10; no. 1; pp. 52 - 12
• Main Authors: Cowell, Annie N., Valdivia, Hugo O., Bishop, Danett K., Winzeler, Elizabeth A.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.07.2018; BioMed Central; BMC
• Subjects: Causes of; Chloroquine; Chromosomes - genetics; Cytochrome; Deoxyribonucleic acid; Discriminant analysis; DNA; DNA sequencing; Drug resistance; Drug Resistance - genetics; Genetic aspects; Genetic Variation; Genomes; Geography; Humans; Infections; Liver; Malaria; Malaria, Vivax - epidemiology; Malaria, Vivax - genetics; Malaria, Vivax - transmission; Mutation; Parasitemia; Parasites; Peru - epidemiology; Phylogeny; Plasmodium vivax; Plasmodium vivax - genetics; Polymorphism, Single Nucleotide - genetics; Population Dynamics; Population genetics; Population structure; Prevention; Primaquine; Proteins; Recurrence; Relapse; Single-nucleotide polymorphism; Specimen Handling; Subpopulations; Time Factors; Tropical diseases; Whole Genome Sequencing; Peru; Plasmodium vivax; Relapse; Malaria; Primaquine; Whole genome sequencing; Population genetics

Plasmodium vivax poses a significant challenge to malaria elimination due to its ability to cause relapsed infections from reactivation of dormant liver parasites called hypnozoites. We analyzed 69 P. vivax whole genome sequences obtained from subjects residing in three different villages along the...