Role of carbonyl sulfide in acute lung injury following limb ischemia/reperfusion in rats

• Published in: European journal of medical research Vol. 22; no. 1; pp. 12 - 8
• Main Authors: Zhao, Yan-Rui, Lv, Wen-Rui, Zhou, Jun-Lin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.03.2017; BioMed Central; BMC
• Subjects: Acute lung injury; Acute Lung Injury - drug therapy; Acute Lung Injury - genetics; Acute Lung Injury - physiopathology; Adult respiratory distress syndrome; Animals; Antioxidants (Nutrients); Apoptosis - drug effects; Carbonyl sulfide; Cell Adhesion Molecules - genetics; Cytokines; Enzymes; Extremities - injuries; Extremities - physiopathology; Fourier transforms; Gases; Health aspects; Humans; Interleukin-6 - genetics; Interleukins; Ischemia; Ischemia/reperfusion; Male; Metabolism; Neutrophils - drug effects; Neutrophils - pathology; Physiological aspects; Rats; Reperfusion Injury - drug therapy; Reperfusion Injury - physiopathology; Rodents; Sulfides; Sulfur; Sulfur Oxides - administration & dosage; Tumor necrosis factor; Tumor Necrosis Factor-alpha - genetics; Beijing China; China; Acute lung injury; Ischemia/reperfusion; Carbonyl sulfide

To investigate the effect of carbonyl sulfide (COS) on limb ischemia/reperfusion (I/R)-induced acute lung injury (ALI) and the associated mechanism in rats. ALI was induced by bilateral hind limb I/R in Sprague-Dawley (SD) rats. Sixty-four SD rats were randomly divided into the control group, I/R gr...