Myocarditis in a patient treated with Nivolumab and PROSTVAC: a case report

• Published in: Journal for immunotherapy of cancer Vol. 6; no. 1; p. 150
• Main Authors: Monge, Cecilia, Maeng, Hoyoung, Brofferio, Alessandra, Apolo, Andrea B, Sathya, Bharath, Arai, Andrew E, Gulley, James L, Bilusic, Marijo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.12.2018; BMJ Publishing Group LTD; BioMed Central; BMJ Publishing Group
• Subjects: Aged; Analysis; Antineoplastic Agents, Immunological - adverse effects; Biopsy; Cancer; Cancer Vaccines - adverse effects; Cardiac arrhythmia; Cardiovascular disease; Care and treatment; Case Report; Case reports; Case studies; Clinical trials; Consent; Ejection fraction; Electrocardiography; Enzymes; Humans; Immunotherapy; Kinases; Male; Metastasis; Monoclonal antibodies; Myocarditis; Myocarditis - chemically induced; Nivolumab; Nivolumab - adverse effects; Patients; Prostate cancer; Prostatic Neoplasms, Castration-Resistant - pathology; Prostatic Neoplasms, Castration-Resistant - therapy; Pulmonary arteries; Risk factors; Targeted cancer therapy; Ultrasonic imaging; Vaccines

Immune checkpoint inhibitors have revolutionized treatment and improved survival in many cancers. However, since immune-related adverse events (irAEs) are potentially fatal, early recognition and prompt treatment are warranted. One of the rarest but most dramatic irAE is myocarditis, which has signi...