Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease

• Published in: Acta neuropathologica communications Vol. 6; no. 1; pp. 113 - 14
• Main Authors: Sengupta, Urmi, Montalbano, Mauro, McAllen, Salome, Minuesa, Gerard, Kharas, Michael, Kayed, Rakez
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.10.2018; BioMed Central; BMC
• Subjects: Advertising executives; Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amino acids; Antigens; Atomic force microscopy; Binding proteins; Brain; Case-Control Studies; Cell cycle; Cell division; Cellular proteins; Cerebral Cortex - metabolism; Cytoplasm; Deoxyribonucleic acid; Disease; DNA; Female; Humans; Immunoprecipitation; Insects; Localization; Male; Medical research; Memory; Microscopy; Microscopy, Atomic Force; Musashi proteins; Nerve Tissue Proteins - metabolism; Neurodegeneration; Oligomers; Protein Aggregation, Pathological - etiology; Protein binding; Proteins; RNA; RNA-Binding Proteins - metabolism; Sarcoma; Stem cells; Superoxides; Tau; tau Proteins - metabolism; Oligomers; Tau; Alzheimer’s disease; Musashi proteins

Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with structural and functional alterations of brain cells causing progressive deterioration of memory and other cognitive functions. Recent studies demonstrate that several neurodegenerative diseases, including AD...