dynamic pause-unpackaging state, an off-translocation recovery state of a DNA packaging motor from bacteriophage T4

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 49; pp. 20000 - 20005
• Main Authors: Kottadiel, Vishal I, Rao, Venigalla B, Chemla, Yann R
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 04.12.2012; National Acad Sciences
• Subjects: Adenosine triphosphatase; Adenosine triphosphatases; adenosine triphosphate; Adenosine Triphosphate - metabolism; ATP; Bacteriophage T4; Bacteriophage T4 - physiology; Bacteriophages; Biological Sciences; Capsid; Deoxyribonucleic acid; DNA; DNA packaging; DNA Packaging - physiology; genome; Genomes; Herpes viruses; kinesin; Kinetics; Models, Biological; Molecular Dynamics Simulation; Molecular Motor Proteins - metabolism; Molecules; Motors; optical traps; Optical Tweezers; Packaging; Proteins; Translocation; Velocity; Viral genomes; Viral Proteins - metabolism; Virus Assembly - physiology

Tailed bacteriophages and herpes viruses use powerful ATP-driven molecular motors to translocate their viral genomes into a preformed capsid shell. The bacteriophage T4 motor, a pentamer of the large terminase protein (gp17) assembled at the portal vertex of the prohead, is the fastest and most powe...