Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer

• Published in: BMC medicine Vol. 15; no. 1; p. 118
• Main Authors: Lubbock, Alexander L R, Stewart, Grant D, O'Mahony, Fiach C, Laird, Alexander, Mullen, Peter, O'Donnell, Marie, Powles, Thomas, Harrison, David J, Overton, Ian M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.06.2017; BioMed Central; BMC
• Subjects: Accuracy; Adult; Age; Aged; Algorithms; Biomarkers; Biomarkers, Tumor - genetics; Cadherins; Cancer; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - physiopathology; Case reports; Cell adhesion & migration; Clear cell-type renal cell carcinoma; Cohort Studies; Confidence intervals; Consortia; Correlation coefficient; Correlation coefficients; Female; Financing; Genetic Heterogeneity; Group dynamics; Health risks; Heterogeneity; Humans; Hypothesis testing; Kidney cancer; Kidney Neoplasms - genetics; Kidney Neoplasms - pathology; Kidney Neoplasms - physiopathology; Male; Mathematical models; Medical prognosis; Metastases; Metastasis; Middle Aged; Morphology; Multivariate analysis; N-Cadherin; Neoplasm Proteins; Patients; Performance prediction; Prognosis; Prognostic markers; Proportional Hazards Models; Protein Array Analysis; Protein arrays; Protein expression; Proteins; Quality; Reclassification; Renal cell carcinoma; Replication; Risk; Risk groups; Sampling; Survival; Survival Rate; TOR protein; Tumor markers; Tumors; Tumour biomarkers; Tumour heterogeneity; Prognostic markers; Tumour biomarkers; Tumour heterogeneity; Renal cell carcinoma; Cancer

Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable investment in molecular risk stratification has sought to overcome the performance ceiling encou...