On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex

• Published in: The Journal of biological chemistry Vol. 284; no. 36; pp. 24242 - 24256
• Main Authors: Patel, Anamika, Dharmarajan, Venkatasubramanian, Vought, Valarie E., Cosgrove, Michael S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.09.2009; American Society for Biochemistry and Molecular Biology
• Subjects: DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Gene Rearrangement - genetics; Histone-Lysine N-Methyltransferase - chemistry; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Histones - chemistry; Histones - genetics; Histones - metabolism; Humans; Intracellular Signaling Peptides and Proteins; Leukemia - genetics; Leukemia - metabolism; Lysine - genetics; Lysine - metabolism; Methylation; Multiprotein Complexes - chemistry; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; Myeloid-Lymphoid Leukemia Protein - chemistry; Myeloid-Lymphoid Leukemia Protein - genetics; Myeloid-Lymphoid Leukemia Protein - metabolism; Nuclear Proteins - chemistry; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Retinol-Binding Proteins, Cellular - chemistry; Retinol-Binding Proteins, Cellular - genetics; Retinol-Binding Proteins, Cellular - metabolism; Transcription Factors - chemistry; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Chromatin, and Epigenetics

Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of H3K4 methyltransferases and is frequently rearranged in acute leukemias. Despite sequence compariso...