Common and Divergent Immune Response Signaling Pathways Discovered in Peripheral Blood Mononuclear Cell Gene Expression Patterns in Presymptomatic and Clinically Apparent Malaria

• Published in: Infection and Immunity Vol. 74; no. 10; pp. 5561 - 5573
• Main Authors: Ockenhouse, Christian F, Hu, Wan-chung, Kester, Kent E, Cummings, James F, Stewart, Ann, Heppner, D. Gray, Jedlicka, Anne E, Scott, Alan L, Wolfe, Nathan D, Vahey, Maryanne, Burke, Donald S
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.10.2006
• Subjects: Adult; antigen presentation; apoptosis; Biological and medical sciences; Culicidae; diagnosis; Female; fever; Fever - genetics; Fundamental and applied biological sciences. Psychology; Fungal and Parasitic Infections; Gene Expression; Gene Expression Profiling; gene expression regulation; Genetic Markers; Genetic Markers - genetics; genetics; Genomics; glycolysis; Glycolysis - genetics; heat stress; Human protozoal diseases; Humans; immune response; Immunity, Active; Immunity, Active - genetics; Immunity, Innate; Immunity, Innate - genetics; immunology; Infectious diseases; inflammation; interferon-gamma; Interferon-gamma - genetics; interleukin-1beta; Leukocytes, Mononuclear; Leukocytes, Mononuclear - immunology; major histocompatibility complex; Malaria; Malaria, Falciparum; Malaria, Falciparum - diagnosis; Malaria, Falciparum - genetics; Male; Medical sciences; Microbiology; mitogen-activated protein kinase; mononuclear leukocytes; Parasitic diseases; patients; phagocytosis; Plasmodium falciparum; Protozoal diseases; Signal Transduction; transcription (genetics); transcription factors; tumor necrosis factor-alpha; Infection; Protozoal disease; Blood cell; Mononuclear cell; Immune response; Microbiology; Malaria; Peripheral blood circulation; Parasitosis; Gene expression; Immunity

Using genome-wide expression profiles from persons either experimentally challenged with malaria-infected mosquitoes or naturally infected with Plasmodium falciparum malaria, we present details of the transcriptional changes that occur with infection and that either are commonly shared between subje...