Structure and Interactions of the Human Programmed Cell Death 1 Receptor

• Published in: The Journal of biological chemistry Vol. 288; no. 17; pp. 11771 - 11785
• Main Authors: Cheng, Xiaoxiao, Veverka, Vaclav, Radhakrishnan, Anand, Waters, Lorna C., Muskett, Frederick W., Morgan, Sara H., Huo, Jiandong, Yu, Chao, Evans, Edward J., Leslie, Alasdair J., Griffiths, Meryn, Stubberfield, Colin, Griffin, Robert, Henry, Alistair J., Jansson, Andreas, Ladbury, John E., Ikemizu, Shinji, Carr, Mark D., Davis, Simon J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.04.2013; American Society for Biochemistry and Molecular Biology
• Subjects: Affinity; Animals; Antigen-Presenting Cells - chemistry; Antigen-Presenting Cells - immunology; Antigen-Presenting Cells - metabolism; B7-1 Antigen - chemistry; B7-1 Antigen - genetics; B7-1 Antigen - immunology; B7-1 Antigen - metabolism; B7-H1 Antigen - chemistry; B7-H1 Antigen - genetics; B7-H1 Antigen - immunology; B7-H1 Antigen - metabolism; Cell Communication - immunology; Cell Surface Protein; Complex Formation; Humans; Immunology; Mice; Models, Immunological; Natural sciences; Naturvetenskap; Nuclear Magnetic Resonance; Nuclear Magnetic Resonance, Biomolecular; Programmed Cell Death 1 Ligand 2 Protein - chemistry; Programmed Cell Death 1 Ligand 2 Protein - genetics; Programmed Cell Death 1 Ligand 2 Protein - immunology; Programmed Cell Death 1 Ligand 2 Protein - metabolism; Programmed Cell Death 1 Receptor - chemistry; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - immunology; Programmed Cell Death 1 Receptor - metabolism; Protein Binding; Protein Structure, Secondary; Receptors; Signaling; Structure-Activity Relationship; Surface Plasmon Resonance; Surface Plasmon Resonance (SPR); T-Lymphocytes - chemistry; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Thermodynamics; Nuclear Magnetic Resonance; Signaling; Thermodynamics; Receptors; Surface Plasmon Resonance (SPR); Cell Surface Protein; Complex Formation; Affinity

PD-1, a receptor expressed by T cells, B cells, and monocytes, is a potent regulator of immune responses and a promising therapeutic target. The structure and interactions of human PD-1 are, however, incompletely characterized. We present the solution nuclear magnetic resonance (NMR)-based structure...