A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle - Martin, Scott; Chiramel, Abhilash I.; Schmidt, Marie Luisa; Chen, Yu-Chi; Whitt, Nadia; Watt, Ari; Dunham, Eric C.; Shifflett, Kyle; Traeger, Shelby; Leske, Anne; Buehler, Eugen; Martellaro, Cynthia; et al. (Genome medicine, 2018)
Keywords: Animals; Antiviral activity; Antiviral Agents - pharmacology; Biosynthesis; Carbamoyl phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase; Cell cycle; Cell Line, Tumor; Cercopithecus aethiops; Cloning, Molecular; De novo pyrimidine synthesis; Dihydroorotate dehydrogenase; Disease resistance; Ebola virus; Ebolavirus; Ebolavirus - drug effects; Ebolavirus - pathogenicity; Ebolavirus - physiology; Gene Knockdown Techniques; Genes; Genetic aspects; Genetic screening; Genome, Human; Genomes; HEK293 Cells; Host factor; Host-Pathogen Interactions - genetics; Humans; Kinases; Life cycles; Outbreaks; Proteins; Replication; RNA viruses; siRNA; Small interfering RNA; Teriflunomide; Transcription; Vero Cells; Virus Replication; Viruses; West Africa; Sudan; Ebola virus; Non-segmented negative-sense RNA viruses; De novo pyrimidine synthesis; NNSV; Carbamoyl phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase; Teriflunomide; siRNA screen; Host factor; Dihydroorotate dehydrogenase